From The Materials Research Institute
In
At
The Pennsylvania State University
5.3.24
Jamie Oberdick
Dipanjan Pan, left, Dorothy Foehr Huck & J. Lloyd Huck Chair Professor in Nanomedicine and professor of materials science and engineering and of nuclear engineering, with Teresa Aditya, postdoctoral researcher in nuclear engineering, and David Skrodzki, graduate research assistant in materials science and engineering, in Pan’s lab. All three were authors of the study. Credit: Dipanjan Pan.
Researchers tweaked borophene to interact with cells and other biological units in unique ways.
Move over, graphene. There’s a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers at Penn State have made the material potentially more useful by imparting chirality — or handedness — on it, which could make for advanced sensors and implantable medical devices. The chirality, induced via a method never before used on borophene, enables the material to interact in unique ways with different biological units such as cells and protein precursors.
The team, led by Dipanjan Pan, Dorothy Foehr Huck & J. Lloyd Huck Chair Professor in Nanomedicine and professor of materials science and engineering and of nuclear engineering, published their work — the first of its kind, they said — in ACS Nano.
“Borophene is a very interesting material, as it resembles carbon very closely including its atomic weight and electron structure but with more remarkable properties. Researchers are only starting to explore its applications,” Pan said. “To the best of our knowledge, this is the first study to understand the biological interactions of borophene and the first report of imparting chirality on borophene structures.”
Chirality refers to similar but not identical physicality, like left and right hands. In molecules, chirality can make biological or chemical units exist in two versions that cannot be perfectly matched, as in a left and right mitten. They can mirror each other precisely, but a left mitten will never fit the right hand as well as it fits the left hand.
Borophene is structurally polymorphic, which means its boron atoms can be arranged in different configurations to give it different shapes and properties, much like how the same set of Lego blocks can be built into different structures. This gives researchers the ability to “tune” borophene to give it various properties, including chirality.
“Since this material has remarkable potential as a substrate for implantable sensors, we wanted to learn about their behavior when exposed to cells,” Pan said. “Our study, for the first time ever, showed that various polymorphic structures of borophene interact with cells differently and their cellular internalization pathways are uniquely dictated by their structures.”
The researchers synthesized borophene platelets — similar to the cellular fragments found in blood — using solution state synthesis, which involves exposing a powdered version of the material in a liquid to one or more external factors, such as heat or pressure, until they combine into the desired product.
“We made the borophene by subjecting the boron powders to high-energy sound waves and then mixed these platelets with different amino acids in a liquid to impart the chirality,” Pan said. “During this process, we noticed that the sulfur atoms in the amino acids preferred to stick to the borophene more than the amino acids’ nitrogen atoms did.”
The researchers found that certain amino acids, like cysteine, would bind to borophene in distinct locations, depending on their chiral handedness. The researchers exposed the chiralized borophene platelets to mammalian cells in a dish and observed that their handedness changed how they interacted with cell membranes and entered cells.
According to Pan, this finding could inform future applications, such as development of higher-resolution medical imaging with contrast that could precisely track cell interactions or better drug delivery with pinpointed material-cell interactions. Critically, he said, understanding how the material interacts with cells — and controlling those interactions — could one day lead to safer, more effective implantable medical devices.
“Borophene’s unique structure allows for effective magnetic and electronic control,” Pan said, noting the material could have additional applications in health care, sustainable energy and more. “This study was just the beginning. We have several projects underway to develop biosensors, drug delivery systems and imaging applications for borophene.”
Along with Pan, other authors of the study include Teresa Aditya, postdoctoral researcher in nuclear engineering; Parikshit Moitra, research assistant professor of nuclear engineering at Penn State during the study and current assistant professor at the Indian Institute of Science Education and Research; Maha Alafeef, research scientist at Penn State during the study and current assistant professor at Jordan University of Science and Technology; and David Skrodzki, graduate research assistant in materials science and engineering at Penn State.
The Centers for Disease Control and Prevention, the U.S. National Science Foundation and the Department of Defense partially supported this research.
See the full article here .
Comments are invited and will be appreciated, especially if the reader finds any errors which I can correct.
five-ways-keep-your-child-safe-school-shootings
Please help promote STEM in your local schools.
Penn State’s Materials Research Institute is a catalyst for multidisciplinary education and innovations in materials. With their capabilities in electronic materials and devices, functional polymers and nanoscience, Penn State is uniquely positioned to apply their materials research to critical challenges of the future in healthcare. It is their vision to apply both the depth and breadth of their collective expertise to engage in research without boundaries, and thereby to create a new generation of highly qualified graduates who can both communicate and innovate in a converging technological world.
The Penn State College of Engineering is the engineering school of the Pennsylvania State University, headquartered at the University Park campus in University Park, Pennsylvania. It was established in 1896, under the leadership of George W. Atherton. Today, with 13 academic departments and degree programs, over 11,000 enrolled undergraduate and graduate students (over 8,000 at the University Park campus, and over 3,000 at other campuses), and annual research expenditures of over $130 million, the Penn State College of Engineering is one of the leading engineering schools in the United States. It is estimated that at least one out of every fifty engineers in the United States got their bachelor’s degree from Penn State.
The appointment of George Atherton as president in 1882 created an era of extraordinary stability and growth for Penn State. Top priority was given to enlarging the engineering program, and Atherton immediately approved an equipment expenditure of $3,000 for practicums and laboratory sessions. Atherton held strongly to the view that Penn State should be an engineering and industrial institution, rather than a classical one, and that classics should not be a “leading object” in a college curriculum. The logical conclusion of this was that mechanic arts were also to be placed on par with agriculture, given the rapid industrialization of the nation. All students now took identical coursework during their freshman and sophomore years, with a specialization in engineering reserved for their junior and senior years.
Additionally, short courses (three in agriculture, one in chemistry, one in mining, and one in elementary mechanics) began to be offered, with no admission or degree requirements.
Despite the improvements to the civil engineering curriculum, Atherton knew that further evolution was needed. To that end, he challenged Louis Reber, a mathematics instructor, to attend The Massachusetts Institute of Technology for graduate work in mechanical engineering – and to pay particular attention to the processes and procedures used for engineering education – in order to develop Penn State’s two-year mechanic arts program into a four-year mechanical engineering curriculum. Reber took to the challenge, and also studied engineering education methods in use at Worcester Polytechnic Institute, Stevens Institute of Technology, Washington University in St. Louis, and The University of Minnesota to establish a baseline for Penn State’s program, which at that time consisted of mechanical drawing, woodworking, and carpentry. Reber also supervised the installation of a forge and foundry, and in 1884 asked for $3,500 to construct new building solely devoted to mechanic arts; Atherton immediately approved Reber’s request, and the resulting building was the first structure erected for purely academic purposes. Machinery and equipment for the building were purchased at reduced prices from equipment manufacturers based on the advertising potential and inherent goodwill to be found in labeling items “for educational purposes.”
In addition to providing instruction, the mechanical engineering department also managed the pumphouse, steam heating plant, and (beginning in 1887) the fifty-horsepower steam engine and generator used to power the incandescent lighting at the campus. The students thus gained practical experience via the chores required to manage and maintain these machines. The creation of the mechanical engineering curriculum segregated students into “general” and “technical” paths (not entirely dissimilar to modern-day general education and major-specific instruction requirements), and the curriculum featured what is now considered “typical” coursework in science and mathematics, as well as several practicums (one for each of the fall, winter, and spring terms) to develop skills such as drawing, pattern making, surveying, chemistry, mechanics, forging, and machine construction.
Thornton Osmond also issued recommendations that electrical engineering be spun off into its own field (it had previously resided in the physics department); Atherton approved this request, and the Department of Physics and Electrotechnics was created in 1887 to explore the practical applications of electricity. The revised engineering curricula proved popular: of the 92 students enrolled for the 1887-88 academic year, over 35% were in engineering (18 mechanical, 15 civil). The subsequent year’s enrollment rose to 113, of which 42% in engineering (22 mechanical, 17 civil, 9 electrical).
The growing popularity of the engineering curricula also required physical growth of the campus. In 1891, $100,000 was allotted to construct a building devoted entirely to engineering. This building, named Main Engineering, was dedicated on February 22, 1893, with most of the dedication speech focused on the importance of an engineering education to national prosperity and progress. Additional machinery, including Allis-Chalmers triple-expansion steam engine (extensively modified for laboratory instruction and experimentation), was purchased and installed. The engineering program continued to expand its offerings: in 1893, the trustees approved the addition of a course in mining engineering, with Magnus C. Ihlseng (formerly of The Colorado School of Mines) named professor and department head. Electrical engineering fully split from Physics and Electrotechnics, becoming its own department headed by John Price Jackson –who, at age 24, is easily the youngest department head on campus. By 1890, Main Engineering housed four engineering departments (civil, mechanical, mining, and electrical) in space originally intended for two. Increases in enrollment remained unceasing: in the 1890-91 academic year there were 127 undergraduates, 73 of which are in engineering (37 civil, 19 mechanical, 17 electrotechnical); by 1893, this had increased to 181 students, 128 in engineering (57 electrical, 44 mechanical, 18 civil, 9 mining). Needless to say, the overcrowding became problematic.
Coursework expansions were also underway. The department of civil engineering began to include instruction in sanitary and hydraulic engineering; however, students still did not yet have the opportunity to specialize in specific facet of desired profession outside of lab and thesis work. In 1894, a new curriculum requirement was added: all freshmen, sophomore, and junior engineering students were required to take a two-week summer course to gain field experience via visits to coal mines, railroad shops, foundries, power stations, and similar businesses. This marked the first offering of a summer session in Penn State history.
The increasing demand led to the formation of seven schools within Penn State. The Second Morrill Act (1890) gave each land-grant institution $15,000, which increased at a rate of $1,000 per year (to a maximum of $25,000), to be invested in instruction in agriculture, mechanic arts, etc. with “specific reference to their applications in the industry of life.” Engineering absorbed most of the at the expense of development of non-technical curricula. Atherton remained convinced that the college should increase instruction in liberal studies for all students, to become “[men] of broad culture and good citizen[s].” To that end, the establishment of the seven schools was intended to eliminate duplication of instruction and resources while also encouraging and facilitating cooperation among related departments. Perhaps most importantly, it also shifted the burden of administration from the president’s office onto the deans. Louis Reber became the first dean of the school of engineering, which exercised authority over the civil, mechanical, and electrical engineering departments. The mining engineering curriculum formed the core for the School of Mines, with Magnus Ihlseng named as dean.
The Pennsylvania State University is a public state-related land-grant research university with campuses and facilities throughout Pennsylvania. Founded in 1855 as the Farmers’ High School of Pennsylvania, Penn State became the state’s only land-grant university in 1863. Today, Penn State is a major research university which conducts teaching, research, and public service. Its instructional mission includes undergraduate, graduate, professional and continuing education offered through resident instruction and online delivery. In addition to its land-grant designation, it also participates in the sea-grant, space-grant, and sun-grant research consortia; it is one of only four such universities (along with Cornell University, Oregon State University, and University of Hawaiʻi at Mānoa). Its University Park campus, which is the largest and serves as the administrative hub, lies within the Borough of State College and College Township. It has two law schools: Penn State Law, on the school’s University Park campus, and Dickinson Law, in Carlisle. The College of Medicine is in Hershey. Penn State is one university that is geographically distributed throughout Pennsylvania. There are 19 commonwealth campuses and 5 special mission campuses located across the state. The University Park campus has been labeled one of the “Public Ivies,” a publicly funded university considered as providing a quality of education comparable to those of the Ivy League.
The Pennsylvania State University is a member of The Association of American Universities an organization of American and Canadian research universities devoted to maintaining a strong system of academic research and education.
Annual enrollment at the University Park campus totals more than 47,000 graduate and undergraduate students, making it one of the largest universities in the United States. It has the world’s largest dues-paying alumni association. The university offers more than 160 majors among all its campuses.
Annually, the university hosts the Penn State IFC/Panhellenic Dance Marathon (THON), which is the world’s largest student-run philanthropy. This event is held at the Bryce Jordan Center on the University Park campus. The university’s athletics teams compete in Division I of the NCAA and are collectively known as the Penn State Nittany Lions, competing in the Big Ten Conference for most sports. Penn State students, alumni, faculty and coaches have received many Olympic medals.
Early years
The school was sponsored by the Pennsylvania State Agricultural Society and founded as a degree-granting institution on February 22, 1855, by Pennsylvania’s state legislature as the Farmers’ High School of Pennsylvania. The use of “college” or “university” was avoided because of local prejudice against such institutions as being impractical in their courses of study. Centre County, Pennsylvania, became the home of the new school when James Irvin of Bellefonte, Pennsylvania, donated 200 acres (0.8 km^2) of land – the first of 10,101 acres (41 km^2) the school would eventually acquire. In 1862, the school’s name was changed to the Agricultural College of Pennsylvania, and with the passage of the Morrill Land-Grant Acts, Pennsylvania selected the school in 1863 to be the state’s sole land-grant college. The school’s name changed to the Pennsylvania State College in 1874; enrollment fell to 64 undergraduates the following year as the school tried to balance purely agricultural studies with a more classic education.
George W. Atherton became president of the school in 1882, and broadened the curriculum. Shortly after he introduced engineering studies, Penn State became one of the ten largest engineering schools in the nation. Atherton also expanded the liberal arts and agriculture programs, for which the school began receiving regular appropriations from the state in 1887. A major road in State College has been named in Atherton’s honor. Additionally, Penn State’s Atherton Hall, a well-furnished and centrally located residence hall, is named not after George Atherton himself, but after his wife, Frances Washburn Atherton. His grave is in front of Schwab Auditorium near Old Main, marked by an engraved marble block in front of his statue.
Early 20th century
In the years that followed, Penn State grew significantly, becoming the state’s largest grantor of baccalaureate degrees and reaching an enrollment of 5,000 in 1936. Around that time, a system of commonwealth campuses was started by President Ralph Dorn Hetzel to provide an alternative for Depression-era students who were economically unable to leave home to attend college.
In 1953, President Milton S. Eisenhower, brother of then-U.S. President Dwight D. Eisenhower, sought and won permission to elevate the school to university status as The Pennsylvania State University. Under his successor Eric A. Walker (1956–1970), the university acquired hundreds of acres of surrounding land, and enrollment nearly tripled. In addition, in 1967, the Penn State Milton S. Hershey Medical Center, a college of medicine and hospital, was established in Hershey with a $50 million gift from the Hershey Trust Company.
Modern era
In the 1970s, the university became a state-related institution. As such, it now belongs to the Commonwealth System of Higher Education. In 1975, the lyrics in Penn State’s alma mater song were revised to be gender-neutral in honor of International Women’s Year; the revised lyrics were taken from the posthumously-published autobiography of the writer of the original lyrics, Fred Lewis Pattee, and Professor Patricia Farrell acted as a spokesperson for those who wanted the change.
In 1989, the Pennsylvania College of Technology in Williamsport joined ranks with the university, and in 2000, so did the Dickinson School of Law. The university is now the largest in Pennsylvania. To offset the lack of funding due to the limited growth in state appropriations to Penn State, the university has concentrated its efforts on philanthropy.
Research
Penn State is classified among “R1: Doctoral Universities – Very high research activity”. Over 10,000 students are enrolled in the university’s graduate school (including the law and medical schools), and over 70,000 degrees have been awarded since the school was founded in 1922.
Penn State’s research and development expenditure has been on the rise in recent years. According to institutional rankings of total research expenditures for science and engineering released by the National Science Foundation , Penn State stood second in the nation, behind only Johns Hopkins University and tied with the Massachusetts Institute of Technology , in the number of fields in which it is ranked in the top ten. Overall, Penn State ranked very highly nationally in total research expenditures across the board. In 12 individual fields, however, the university achieved rankings in the top ten nationally. The fields and sub-fields in which Penn State ranked in the top ten are materials, psychology, mechanical engineering, sociology, electrical engineering, total engineering, aerospace engineering, computer science, agricultural sciences, civil engineering, atmospheric sciences, and earth sciences. Moreover, in eleven of these fields, the university has repeated top-ten status every year since at least 2008.
The Applied Research Lab (ARL), located near the University Park campus, has been a research partner with the Department of Defense since 1945 and conducts research primarily in support of the United States Navy. It is the largest component of Penn State’s research efforts statewide, with over 1,000 researchers and other staff members.
The Materials Research Institute was created to coordinate the highly diverse and growing materials activities across Penn State’s University Park campus. With more than 200 faculty in 15 departments, 4 colleges, and 2 Department of Defense research laboratories, MRI was designed to break down the academic walls that traditionally divide disciplines and enable faculty to collaborate across departmental and even college boundaries. MRI has become a model for this interdisciplinary approach to research, both within and outside the university. Dr. Richard E. Tressler was an international leader in the development of high-temperature materials. He pioneered high-temperature fiber testing and use, advanced instrumentation and test methodologies for thermostructural materials, and design and performance verification of ceramics and composites in high-temperature aerospace, industrial, and energy applications. He was founding director of the Center for Advanced Materials (CAM), which supported many faculty and students from the College of Earth and Mineral Science, the Eberly College of Science, the College of Engineering, the Materials Research Laboratory and the Applied Research Laboratories at Penn State on high-temperature materials. His vision for Interdisciplinary research played a key role in creating the Materials Research Institute, and the establishment of Penn State as an acknowledged leader among major universities in materials education and research.
The university was one of the founding members of the Worldwide Universities Network (WUN), a partnership that includes 17 research-led universities in the United States, Asia, and Europe. The network provides funding, facilitates collaboration between universities, and coordinates exchanges of faculty members and graduate students among institutions. Former Penn State president Graham Spanier is a former vice-chair of the WUN.
The university’s library system began with a 1,500-book library in Old Main.
The university’s College of Information Sciences and Technology is the home of CiteSeerX, an open-access repository and search engine for scholarly publications. The university is also the host to the Radiation Science & Engineering Center, which houses the oldest operating university research reactor. Additionally, University Park houses the Graduate Program in Acoustics, the only freestanding acoustics program in the United States. The university also houses the Center for Medieval Studies, a program that was founded to research and study the European Middle Ages, and the Center for the Study of Higher Education (CSHE), one of the first centers established to research postsecondary education.
sciencesprings 