Research reveals lactic acid’s role in lung disease
“Results:Expertise at Pacific Northwest National Laboratory contributed to the understanding of the role of cellular metabolism in the pathogenesis of a currently untreatable lung disease. This research, reported in the American Journal of Respiratory and Critical Care Medicine, highlights the importance of PNNL’s nuclear magnetic resonance (NMR) metabolomics in the field of biomedicine.
Top: Lactic acid concentrations were measured in whole lung homogenates using ¹H-PASS nuclear magnetic resonance (NMR) spectroscopy obtained from patients with idiopathic pulmonary fibrosis (IPF) and compared with healthy control subjects. Bottom: Lactate dehydrogenase-5 (LDH5) expression is elevated in fibroblasts and lung tissue from IPF patients. LDH5 is responsible for the generation of lactic acid. Immunohistochemistry is shown for LDH5 performed on lung tissue sections from a healthy control subject (left) and a patient with IPF (right). LDH5 expression, shown as the reddish-brown stained area, is increased in the lung tissue of patients with IPF.
Why It Matters: Scientists increasingly recognize that dysregulated, or impaired, cellular metabolism impacts disease processes. However, they know little about the role of cellular metabolism as it relates to lung disease. Greater understanding of the dysregulated processes in human diseases will help in developing improved diagnostic and treatment strategies.”
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Pacific Northwest National Laboratory (PNNL) is one of the United States Department of Energy National Laboratories, managed by the Department of Energy’s Office of Science. The main campus of the laboratory is in Richland, Washington.
PNNL scientists conduct basic and applied research and development to strengthen U.S. scientific foundations for fundamental research and innovation; prevent and counter acts of terrorism through applied research in information analysis, cyber security, and the nonproliferation of weapons of mass destruction; increase the U.S. energy capacity and reduce dependence on imported oil; and reduce the effects of human activity on the environment. PNNL has been operated by Battelle Memorial Institute since 1965.
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