From The DOE’s Pacific Northwest National Laboratory: “BIGTUNA Bioimaging Tool Helps Researchers See Small”

From The DOE’s Pacific Northwest National Laboratory

3.28.23
Rebekah Orton | PNNL

Novel nano-optical technology tracks communications in living cells.

An illustration of how next-generation bioimager BIGTUNA simultaneously uses multiple approaches to significantly improve metabolic mapping. (Image by Nathan Johnson | Pacific Northwest National Laboratory)

Microbes may be among the smallest living things on Earth, but bioimaging to understand the chemistry that fuels these organisms could reveal important clues about the intricacies of gene function and the health of the planet. Because of this, scientists have long sought ways to eavesdrop on conversations between living microbes in their environment.

This has been exceptionally difficult, in part because microbes communicate using molecules instead of words. Deciphering conversations means identifying small, specific, and quickly changing molecules called metabolites, something even the most powerful instruments struggle to attempt. But a team of researchers at Pacific Northwest National Laboratory (PNNL) have spent the last decade continuously developing a next-generation bioimaging instrument that is making progress toward this goal.

The Chemical Dynamics Initiative (CDi), an internal PNNL investment, supported PNNL chemist Patrick El Khoury and his team as they developed the technology to measure phenomena in the quantum realm. Here [?] the team imaged subatomic waves of energy called phonons as they formed, beat, and dissipated in a single trillionth of a second.

“Similar technologies can be used to image phonons and metabolites in real space and real time,” said El Khoury. “The fundamental advances required in both areas comprise a challenge worthy of a national laboratory and continued investments.”

Now researchers are taking the technologies to the next level as they use bioimaging to map metabolites exchanged by live microbes.

Bioimaging to fish out whispers in a crowd

The bioimager is known as BIGTUNA, short for BioImaginG Technology Using Nano-optical Approach. The keys to BIGTUNA are its multiple optical capabilities, each providing complementary information about the position and composition of molecules in a study sample. Many laser sources focus on the tip of a very sharp nanosized needle. Researchers position the needle’s tip in the sample area they want to examine, then use the light focused on the tip of the needle to measure the sample’s physical and chemical features. Through this, researchers identify molecules and understand how they interact.

Chemical bioimaging with light has been done for a hundred years but never at this molecular scale.

“Some methods illuminate a relatively large area, but these far-field approaches are like listening in to a crowd and expecting to understand individual conversations,” said PNNL chemist Scott Lea. To overcome this challenge, researchers focused on combining a wide range of near-field techniques to capture and characterize the maximum information in an area as small as a few molecules.

“If we don’t have multiple streams of data coming from multiple techniques, we only get partial information,” said El Khoury. “And in addition to developing the techniques, we developed our understanding of optical selection rules to maximize the information we get from one sample in one set-up.”

In the most recent iteration of this project, the researchers zoomed out to a larger area, although still only a thousandth the thickness of a strand of hair. At this slightly farther distance, they identified the most promising approaches to capture information about the patterns of molecular bonds and the distribution of electrons. These new nano-optical measurements are addressing a much smaller number of molecules; therefore, the researchers must continue developing new theories that describe nanoscopic interactions of light and matter.

One of the custom-built nano-optical system precursors to the BIGTUNA bioimaging device. (Photo by Patrick El-Khoury | Pacific Northwest National Laboratory)

Combining these conceptual and technological developments will allow the researchers to move beyond model systems they studied using early incarnations of BIGTUNA. The chemical signals in these model systems were much stronger than chemical signals from the metabolites involved in microbial communications. In addition to having weaker signals, biological samples are also susceptible to damage by light, which is why BIGTUNA’s noninvasive approach makes it ideal to develop for bioimaging applications. Including state-of-the art data and computational techniques from PNNL data scientists Sarah Akers and Edo Aprà will help automate where and how the instrument balances exploration with the sensitivity of a living system.

Bioimaging to tune in to talking microbes

As an initial foray into biology, researchers are focusing BIGTUNA’s bioimaging power on a community of symbiotic microbes that live in deep ocean sediments. One microbe reduces sulfur, the other oxidizes methane, a powerful greenhouse gas.

Image of the microbe community (purple and green) within sediment particles (yellow) that researchers are studying through bioimaging with BIGTUNA. (Image courtesy of Patrick El Khoury | Pacific Northwest National Laboratory)

Previous approaches to unraveling microbial interactions have mainly focused on identifying influential genes or on examining isolated enzymes and pathways. The approaches often include fixing, freezing, or combining the biological system. But these approaches lose out on time-dependent or space-specific details. And the researchers can’t look at the flow of metabolites to get a predictive understanding of how and why microbes interact.

Even so, PNNL collaborator and CalTech geologist Victoria Orphan has theories about how these symbiotic microbes share metabolites. Bioimaging with BIGTUNA could produce the first close-up view of the metabolites in action as the instrument sends light through the sample and measures what gets absorbed or scattered. Researchers use the information to identify metabolites and create a detailed record of microbial intercellular communication pathways. In turn, this knowledge could help researchers understand the degree to which microbes respond to environmental changes.

A new generation of nano-optics

“Possibilities for BIGTUNA extend far beyond the realm of bioimaging,” said Peter Sushko, CDi’s chief scientist. “Because this highly adaptable instrument can obtain detailed information describing atomic motion and electronic processes, it will be useful in seeking answers to a broad range of questions that are of interest to chemists, physicists, and materials scientists as well.”

Potential applications include quantum materials, catalysis, and human health, in addition to the current work in microbial systems. In that realm, planned future developments could incorporate environmental controls to further generalize the approach.

A portion of the blueprint for BIGTUNA was designed under PNNL’s CDi, a five-year internal investment in capabilities to better understand and predict the evolution of complex chemical systems in real-world or operational environments. The investment has also supported pioneering AI and atomic resolution microscopy, tracking radioiodine for human health and nuclear nonproliferation, perceiving quantum pathways, and developing a 3-D printing approach to produce engineered microporous polymer-containing composite structures.

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The DOE’s Pacific Northwest National Laboratory (PNNL) is one of the United States Department of Energy National Laboratories, managed by the Department of Energy’s Office of Science. The main campus of the laboratory is in Richland, Washington.

PNNL scientists conduct basic and applied research and development to strengthen U.S. scientific foundations for fundamental research and innovation; prevent and counter acts of terrorism through applied research in information analysis, cyber security, and the nonproliferation of weapons of mass destruction; increase the U.S. energy capacity and reduce dependence on imported oil; and reduce the effects of human activity on the environment. PNNL has been operated by Battelle Memorial Institute since 1965.

From The DOE’s Sandia National Laboratories: “Ultrafast beam-steering breakthrough at Sandia Labs”

From The DOE’s Sandia National Laboratories

3.20.23
Neal Singer
nsinger@sandia.gov
505-977-7255

Mollie Rappe
mrappe@sandia.gov
505-228-6123.

As a red beam of light is reflected in an arch, Prasad Iyer, right, and Igal Brener demonstrate optical hardware used for beam steering experiments at Sandia National Laboratories’ Center for Integrated Nanotechnologies. (Photo by Craig Fritz)

In a major breakthrough in the fields of nanophotonics and ultrafast optics, a Sandia National Laboratories research team has demonstrated the ability to dynamically steer light pulses from conventional, so-called incoherent light sources.

This ability to control light using a semiconductor device could allow low-power, relatively inexpensive sources like LEDs or flashlight bulbs to replace more powerful laser beams in new technologies such as holograms, remote sensing, self-driving cars and high-speed communication.

“What we’ve done is show that steering a beam of incoherent light can be done,” said Prasad Iyer, Sandia scientist and lead author of the research, which was reported in the current issue of the journal Nature Photonics [below]. The work was funded by the Department of Energy’s Office of Science.

Incoherent light is emitted by many common sources such as an old-fashioned incandescent light bulb or an LED bulb. This light is called incoherent since the photons are emitted with different wavelengths and in a random fashion. A beam of light from a laser, however, does not spread and diffuse because the photons have the same frequency and phase and is thus called coherent light.

In the team’s research, they manipulated incoherent light by using artificially structured materials called metasurfaces, made from tiny building blocks of semiconductors called meta-atoms that can be designed to reflect light very efficiently. Although metasurfaces had previously shown promise for creating devices that could steer light rays to arbitrary angles, they also presented a challenge because they had only been designed for coherent light sources. Ideally, one would want a semiconductor device that can emit light like an LED, steer the light emission to a set angle by applying a control voltage and shift the steering angle at the fastest speed possible.

A metasurface sample is used for the beam steering with each reflective patch containing thousands of meta-atoms designed to dynamically steer incoherent light. (Photo by Craig Fritz)

The researchers started with a semiconductor metasurface that had embedded tiny light sources called quantum dots. By using a control optical pulse, they were able to change, or reconfigure, the way the surface reflected light and steer the light waves emitted from the quantum dots in different directions over a 70-degree range for less than a trillionth-of-a-second, marking a significant success. Similar to laser-based steering, the steered beam restrained the tendency of incoherent light to spread over a wider viewing angle and instead produced bright light at a distance.

Taming light

A feat previously considered impossible, the team’s proof-of-principle work paves the way for developments in the fields of nanophotonics and ultrafast optics. The ability to dynamically control incoherent light sources and manipulate their properties offers a wide range of applications.

One low-power use would be to brighten military helmet screens used to overlay maps or blueprints over ordinary vision. “In applications where space is valuable,” Iyer said, “steering light emission with low-size-and-weight metasurface-LED displays could be made possible in the future with this technology. We can use the light emitted in a better way rather than just turning them off and on.”

The technique could also provide a new kind of small display that can project holographic images onto eyeballs using low-power LEDs, a capability of particular interest for augmented and virtual reality devices. Other uses could be in self-driving cars where LIDAR is used to sense objects in the path of the car.

In terms of expressions of interest, the team has had several inquiries from commercial sources, said Sandia researcher Igal Brener, a paper author and lead scientist on the project. “A commercial product could be 5-10 years out, especially if we want to have all the functionality on-chip,” Brener said. “You wouldn’t use a control optical pulse to impart the changes in the metasurface needed to steer the light, but rather you would do this control electrically. We have ideas and plans, but it’s still early. Imagine an LED light bulb that can emit light to follow you. Then you wouldn’t waste all that illumination where there’s nobody. This is one of the many applications that we dreamed about with DOE years ago for energy efficiency for office lighting, for example.”

Similarly, tamed light may one day offer benefits in scenarios where focused illumination is only needed in a specific area of interest, such as surgery or in autonomous vehicles.

For incoherent light, the future is looking bright.

Nature Photonics

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Sandia Campus.

Sandia National Laboratories managed and operated by the National Technology and Engineering Solutions of Sandia (a wholly owned subsidiary of Honeywell International), is one of three National Nuclear Security Administration research and development laboratories in the United States. Their primary mission is to develop, engineer, and test the non-nuclear components of nuclear weapons and high technology. Headquartered in Central New Mexico near the Sandia Mountains, on Kirtland Air Force Base in Albuquerque, Sandia also has a campus in Livermore, California, next to DOE’s Lawrence Livermore National Laboratory, and a test facility in Waimea, Kauai, Hawaii.

It is Sandia’s mission to maintain the reliability and surety of nuclear weapon systems, conduct research and development in arms control and nonproliferation technologies, and investigate methods for the disposal of the United States’ nuclear weapons program’s hazardous waste.

Other missions include research and development in energy and environmental programs, as well as the surety of critical national infrastructures. In addition, Sandia is home to a wide variety of research including computational biology; mathematics (through its Computer Science Research Institute); materials science; alternative energy; psychology; MEMS; and cognitive science initiatives.

Sandia formerly hosted ASCI Red, one of the world’s fastest supercomputers until its recent decommission, and now hosts ASCI Red Storm supercomputer, originally known as Thor’s Hammer.

ASCI Red Storm Cray superrcomputer at DOE’s Sandia National Laboratory.

Sandia is also home to the Z Machine.

Sandia Z machine

The Z Machine is the largest X-ray generator in the world and is designed to test materials in conditions of extreme temperature and pressure. It is operated by Sandia National Laboratories to gather data to aid in computer modeling of nuclear guns. In December 2016, it was announced that National Technology and Engineering Solutions of Sandia, under the direction of Honeywell International, would take over the management of Sandia National Laboratories starting on May 1, 2017.

From The University of Rochester: “Perovskites-a ‘dirt cheap’ alternative to silicon-just got a lot more efficient”

From The University of Rochester

2.16.23
Bob Marcotte
bmarcotte@ur.rochester.edu

A perovskite crystalline stone isolated on white background. Perovskites, like the one shown here, show great potential as light-absorbing material for solar harvesting. (Getty Images photo)

The secret-a University of Rochester optics professor explains-is to harness the power of metals.

Silicon, the standard semiconducting material used in a host of applications—computer central processing units (CPUs), semiconductor chips, detectors, and solar cells—is an abundant and naturally occurring material. However, it is expensive to mine and to purify.

Perovskites—a family of materials nicknamed for their crystalline structure—have shown extraordinary promise in recent years as a far less expensive, equally efficient replacement for silicon in solar cells and detectors. Now, a study led by Chunlei Guo, a professor of optics at the University of Rochester, suggests perovskites may become far more efficient.

Researchers typically synthesize perovskites in a wet lab, and then apply the material as a film on a glass substrate and explore various applications

Guo instead proposes a novel, physics-based approach. By using a substrate of either a layer of metal or alternating layers of metal and dielectric material—rather than glass—he and his coauthors found they could increase the perovskite’s light conversion efficiency by 250 percent.

Their findings are reported in Nature Photonics [below].

“No one else has come to this observation in perovskites,” Guo says. “All of a sudden, we can put a metal platform under a perovskite utterly changing the interaction of the electrons within the perovskite. Thus, we use a physical method to engineer that interaction.”

Novel perovskite-metal combination creates ‘a lot of surprising physics’

This illustration from the Guo Lab shows the interaction between a perovskite material (cyan) and a substrate of metal-dielectric material. The red and blue pairings are electron-hole pairs. Mirror images reflected from the substrate reduce the ability of excited electrons in the perovskite to recombine with their atomic cores, increasing the efficiency of the perovskite to harvest solar light. (Illustration by Chloe Zhang)

Metals are probably the simplest materials in nature, but they can be made to acquire complex functions. The Guo Lab has extensive experience in this direction. The lab has pioneered a range of technologies transforming simple metals to pitch black, superhydrophilic (water-attracting), or superhydrophobic (water-repellent). The enhanced metals have been used for solar energy absorption and water purification in their recent studies.

In this new paper, instead of presenting a way to enhance the metal itself, the Guo Lab demonstrates how to use the metal to enhance the efficiency of pervoskites.

“A piece of metal can do just as much work as complex chemical engineering in a wet lab,” says Guo, adding that the new research may be particularly useful for future solar energy harvesting.”

In a solar cell, photons from sunlight need to interact with and excite electrons, causing the electrons to leave their atomic cores and generating an electrical current, Guo explains. Ideally, the solar cell would use materials that are weak to pull the excited electrons back to the atomic cores and stop the electrical current.

Guo’s lab demonstrated that such recombination could be substantially prevented by combining a perovskite material with either a layer of metal or a metamaterial substrate consisting of alternating layers of silver, a noble metal, and aluminum oxide, a dielectric.

The result was a significant reduction of electron recombination through “a lot of surprising physics,” Guo says. In effect, the metal layer serves as a mirror, which creates reversed images of electron-hole pairs, weakening the ability of the electrons to recombine with the holes.

The lab was able to use a simple detector to observe the resulting 250 percent increase in efficiency of light conversion.

Several challenges must be resolved before perovskites become practical for applications especially their tendency to degrade relatively quickly. Currently, researchers are racing to find new, more stable perovskite materials.

“As new perovskites emerge, we can then use our physics-based method to further enhance their performance,” Guo says.

Coauthors include Kwang Jin Lee, Ran Wei, Jihua Zhang, and Mohamed Elkabbash, all current and former members of the Guo Lab, and Ye Wang, Wenchi Kong, Sandeep Kumar Chamoli, Tao Huang, and Weili Yu, all of the Changchun Institute of Optics, Fine Mechanics, and Physics in China.

The Bill and Melinda Gates Foundation, the Army Research Office, and the National Science Foundation supported this research.

Nature Photonics

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University of Rochester campus

The University of Rochester is a private research university in Rochester, New York. The university grants undergraduate and graduate degrees, including doctoral and professional degrees.

The University of Rochester enrolls approximately 6,800 undergraduates and 5,000 graduate students. Its 158 buildings house over 200 academic majors. According to the National Science Foundation , The University of Rochester spent $370 million on research and development in 2018, ranking it 68th in the nation. The University of Rochester is the 7th largest employer in the Finger lakes region of New York.

The College of Arts, Sciences, and Engineering is home to departments and divisions of note. The Institute of Optics was founded in 1929 through a grant from Eastman Kodak and Bausch and Lomb as the first educational program in the US devoted exclusively to Optics and awards approximately half of all Optics degrees nationwide and is widely regarded as the premier Optics program in the nation and among the best in the world.

The Departments of Political Science and Economics have made a significant and consistent impact on positivist social science since the 1960s and historically rank in the top 5 in their fields. The Department of Chemistry is noted for its contributions to synthetic Organic Chemistry, including the first lab-based synthesis of morphine. The Rossell Hope Robbins Library serves as The University of Rochester’s resource for Old and Middle English texts and expertise. The university is also home to Rochester’s Laboratory for Laser Energetics, a Department of Energy supported national laboratory.

The University of Rochester Laboratory for Laser Energetics.

The University of Rochester’s Eastman School of Music ranks first among undergraduate music schools in the U.S. The Sibley Music Library at Eastman is the largest academic music library in North America and holds the third largest collection in the United States.

In its history The University of Rochester alumni and faculty have earned 13 Nobel Prizes; 13 Pulitzer Prizes; 45 Grammy Awards; 20 Guggenheim Awards; 5 National Academy of Sciences; 4 National Academy of Engineering; 3 Rhodes Scholarships; 3 National Academy of Inventors; and 1 National Academy of Inventors Hall of Fame.

History

Early history

The University of Rochester traces its origins to The First Baptist Church of Hamilton (New York) which was founded in 1796. The church established the Baptist Education Society of the State of New York later renamed the Hamilton Literary and Theological Institution in 1817. This institution gave birth to both Colgate University and the University of Rochester. Its function was to train clergy in the Baptist tradition. When it aspired to grant higher degrees it created a collegiate division separate from the theological division.

The collegiate division was granted a charter by the State of New York in 1846 after which its name was changed to Madison University. John Wilder and the Baptist Education Society urged that the new university be moved to Rochester, New York. However, legal action prevented the move. In response, dissenting faculty, students, and trustees defected and departed for Rochester, where they sought a new charter for a new university.

Madison University was eventually renamed as Colgate University.

Founding

Asahel C. Kendrick- professor of Greek- was among the faculty that departed Madison University for The University of Rochester. Kendrick served as acting president while a national search was conducted. He reprised this role until 1853 when Martin Brewer Anderson of the Newton Theological Seminary in Massachusetts was selected to fill the inaugural posting.

The University of Rochester’s new charter was awarded by the Regents of the State of New York on January 31, 1850. The charter stipulated that The University of Rochester have $100,000 in endowment within five years upon which the charter would be reaffirmed. An initial gift of $10,000 was pledged by John Wilder which helped catalyze significant gifts from individuals and institutions.

Classes began that November with approximately 60 students enrolled including 28 transfers from Madison. From 1850 to 1862 the university was housed in the old United States Hotel in downtown Rochester on Buffalo Street near Elizabeth Street- today West Main Street near the I-490 overpass. On a February 1851 visit Ralph Waldo Emerson said of the university:

“They had bought a hotel, once a railroad terminus depot, for $8,500, turned the dining room into a chapel by putting up a pulpit on one side, made the barroom into a Pythologian Society’s Hall, & the chambers into Recitation rooms, Libraries, & professors’ apartments, all for $700 a year. They had brought an omnibus load of professors down from Madison bag and baggage… called in a painter and sent him up the ladder to paint the title “University of Rochester” on the wall, and they had runners on the road to catch students. And they are confident of graduating a class of ten by the time green peas are ripe.”

For the next 10 years The University of Rochester expanded its scope and secured its future through an expanding endowment; student body; and faculty. In parallel a gift of 8 acres of farmland from local businessman and Congressman Azariah Boody secured the first campus of The University of Rochester upon which Anderson Hall was constructed and dedicated in 1862. Over the next sixty years this Prince Street Campus grew by a further 17 acres and was developed to include fraternity houses; dormitories; and academic buildings including Anderson Hall; Sibley Library; Eastman and Carnegie Laboratories the Memorial Art Gallery and Cutler Union.

Twentieth century

Coeducation

The first female students were admitted in 1900- the result of an effort led by Susan B. Anthony and Helen Barrett Montgomery. During the 1890s a number of women took classes and labs at The University of Rochester as “visitors” but were not officially enrolled nor were their records included in the college register. President David Jayne Hill allowed the first woman- Helen E. Wilkinson- to enroll as a normal student although she was not allowed to matriculate or to pursue a degree. Thirty-three women enrolled among the first class in 1900 and Ella S. Wilcoxen was the first to receive a degree in 1901. The first female member of the faculty was Elizabeth Denio who retired as Professor Emeritus in 1917. Male students moved to River Campus upon its completion in 1930 while the female students remained on the Prince Street campus until 1955.

Expansion

Major growth occurred under the leadership of Benjamin Rush Rhees over his 1900-1935 tenure. During this period George Eastman became a major donor giving more than $50 million to the university during his life. Under the patronage of Eastman the Eastman School of Music was created in 1921. In 1925 at the behest of the General Education Board and with significant support for John D. Rockefeller George Eastman and Henry A. Strong’s family medical and dental schools were created. The university award its first Ph.D that same year.

During World War II The University of Rochester was one of 131 colleges and universities nationally that took part in the V-12 Navy College Training Program which offered students a path to a Navy commission. In 1942, The University of Rochester was invited to join the Association of American Universities as an affiliate member and it was made a full member by 1944. Between 1946 and 1947 in infamous uranium experiments researchers at the university injected uranium-234 and uranium-235 into six people to study how much uranium their kidneys could tolerate before becoming damaged.

In 1955 the separate colleges for men and women were merged into The College on the River Campus. In 1958 three new schools were created in engineering, business administration and education. The Graduate School of Management was named after William E. Simon- former Secretary of the Treasury in 1986. He committed significant funds to the school because of his belief in the school’s free market philosophy and grounding in economic analysis.

Financial decline and name change controversy

Following the princely gifts given throughout his life George Eastman left the entirety of his estate to The University of Rochester after his death by suicide. The total of these gifts surpassed $100 million before inflation and as such The University of Rochester enjoyed a privileged position amongst the most well endowed universities. During the expansion years between 1936 and 1976 The University of Rochester’s financial position ranked third, near Harvard University’s endowment and the University of Texas System’s Permanent University Fund . Due to a decline in the value of large investments and a lack of portfolio diversity The University of Rochester ‘s place dropped to the top 25 by the end of the 1980s. At the same time the preeminence of the city of Rochester’s major employers began to decline.

In response The University of Rochester commissioned a study to determine if the name of the institution should be changed to “Eastman University” or “Eastman Rochester University”. The study concluded a name change could be beneficial because the use of a place name in the title led respondents to incorrectly believe it was a public university, and because the name “Rochester” connoted a “cold and distant outpost.” Reports of the latter conclusion led to controversy and criticism in the Rochester community. Ultimately, the name “The University of Rochester” was retained.

Renaissance Plan
In 1995 The University of Rochester president Thomas H. Jackson announced the launch of a “Renaissance Plan” for The University of Rochester that reduced enrollment from 4,500 to 3,600 creating a more selective admissions process. The plan also revised the undergraduate curriculum significantly creating the current system with only one required course and only a few distribution requirements known as clusters. Part of this plan called for the end of graduate doctoral studies in Chemical Engineering; comparative literature; linguistics; and Mathematics, the last of which was met by national outcry. The plan was largely scrapped and Mathematics exists as a graduate course of study to this day.

Twenty-first century

Meliora Challenge

Shortly after taking office university president Joel Seligman commenced the private phase of the “Meliora Challenge”- a $1.2 billion capital campaign- in 2005. The campaign reached its goal in 2015- a year before the campaign was slated to conclude. In 2016, The University of Rochester announced the Meliora Challenge had exceeded its goal and surpassed $1.36 billion. These funds were allocated to support over 100 new endowed faculty positions and nearly 400 new scholarships.

The Mangelsdorf Years

On December 17, 2018 The University of Rochester announced that Sarah C. Mangelsdorf would succeed Richard Feldman as President of the University. Her term started in July 2019 with a formal inauguration following in October during Meliora Weekend. Mangelsdorf is the first woman to serve as President of the University and the first person with a degree in psychology to be appointed to Rochester’s highest office.

In 2019 students from China mobilized by the Chinese Students and Scholars Association (CSSA) defaced murals in the University’s access tunnels which had expressed support for the 2019 Hong Kong Protests, condemned the oppression of the Uighurs, and advocated for Taiwanese independence. The act was widely seen as a continuation of overseas censorship of Chinese issues. In response a large group of students recreated the original murals. There have also been calls for Chinese government run CSSA to be banned from campus.

Research

The University of Rochester is a member of the Association of American Universities and is classified among “R1: Doctoral Universities – Very High Research Activity”.

The University of Rochester had a research expenditure of $370 million in 2018.

In 2008 The University of Rochester ranked 44th nationally in research spending but this ranking has declined gradually to 68 in 2018.

Some of the major research centers include the Laboratory for Laser Energetics, a laser-based nuclear fusion facility, and the extensive research facilities at the University of Rochester Medical Center.

Recently The University of Rochester has also engaged in a series of new initiatives to expand its programs in Biomedical Engineering and Optics including the construction of the new $37 million Robert B. Goergen Hall for Biomedical Engineering and Optics on the River Campus.

Other new research initiatives include a cancer stem cell program and a Clinical and Translational Sciences Institute. The University of Rochester also has the ninth highest technology revenue among U.S. higher education institutions with $46 million being paid for commercial rights to university technology and research in 2009. Notable patents include Zoloft and Gardasil. WeBWorK, a web-based system for checking homework and providing immediate feedback for students was developed by The University of Rochester professors Gage and Pizer. The system is now in use at over 800 universities and colleges as well as several secondary and primary schools. The University of Rochester scientists work in diverse areas. For example, physicists developed a technique for etching metal surfaces such as platinum; titanium; and brass with powerful lasers enabling self-cleaning surfaces that repel water droplets and will not rust if tilted at a 4 degree angle; and medical researchers are exploring how brains rid themselves of toxic waste during sleep.

From The Swiss Federal Institute of Technology in Lausanne [EPFL-École Polytechnique Fédérale de Lausanne] (CH): “Chromo-encryption method encodes secrets with color”

From The Swiss Federal Institute of Technology in Lausanne [EPFL-École Polytechnique Fédérale de Lausanne] (CH)

2.13.23
Celia Luterbacher

In a new approach to security that unites technology and art, EPFL researchers have combined silver nanostructures with polarized light to yield a range of brilliant colors which can be used to encode messages.

Cryptography is something of a new field for Olivier Martin, who has been studying the optics of nanostructures for many years as head of the Nanophotonics and Metrology Lab EPFL’s School of Engineering. But after developing some new silver nanostructures in collaboration with the Center of MicroNanoTechnology, Martin and PhD student Hsiang-Chu Wang noticed that these nanostructures reacted to polarized light in an unexpected way, which just happened to be perfect for encoding information.

They found that when polarized light was shone through the nanostructures from certain direction a range of vivid and easily-identifiable colors was reflected back. These different colors could be assigned numbers, which could then be used to represent letters using the electronic communication standard code ASCII (American Standard Code for Information Interchange). To encode a secret message, the researchers applied a quaternary code using the digits 0, 1, 2 and 3 (as opposed to the more commonly used binary code 0 and 1). The result was a series of four-digit strings composed of different color combinations that could be used to spell out a message, and the method of chromo-encryption was born.

For example, using their system, the color sequence orange, yellow, red, white represented the digits 1, 0, 2, 0, respectively; a string of numbers which in turn coded for the letter ‘H’ in the secret test message ‘Hello!’.

“Each color code is not unique, meaning that the same digit – 0, 1, 2 or 3 – may represent a different color. This means the encryption system is even more secure, because the chance of guessing the correct code sequence is smaller,” Martin explains. The lab’s results have recently been published in the journal Advanced Optical Materials [below].

The top row represents the message “Hello!” in quaternary code, which is revealed when the silver nanostructures are illuminated with the correct polarization. The bottom two rows display incorrect sequences when incorrect polarization keys are used. © NAM EPFL.

A surprising response to light

At the heart of the new method lies the silver nanostructures’ unique reaction to polarized light. The different hues that the researchers observed were first produced by varying the length and position of the nanostructures. Next, the researchers shone polarized light onto them, meaning that the light waves oscillated in controlled directions (vertically, horizontally, or diagonally). Depending on the polarization direction, the light reflected from the nanostructures changed from dull to vivid, yielding robust colors that were then sent through a second polarizer for analysis.

Crucially, in the chromo-encryption method, only the correct combination of polarization directions would reveal the secret message; light polarized in any other direction would reveal a series of colors corresponding to a nonsense message.

Martin explains that to their surprise, the nanostructures exhibited what is known as a chiral response, as they reflected the polarized light in a different direction than the excitation itself. In physics and chemistry, chirality – or the properties of a material that arise from its geometric asymmetry – is an important and well-studied functional aspect of molecules like proteins. But it was not expected to be seen in the symmetrical silver nanostructures.

“Chirality is a concept that is often misused, and is difficult to nail down. The fundamental aspect of chirality in simple geometries like those exhibited by our nanostructures is a key finding of this study.”

Combining technology with the human eye

In addition to encoding messages, the researchers demonstrated that they could use their method to reproduce a painting – in this case, Picasso’s Mediterranean Landscape – at the nanometer scale. To achieve this, they replaced the pixels of a digital reproduction of the painting with their silver nanostructures. Just as with the chromo-encryption method, the artwork was only revealed when light polarized in the correct direction was shone onto the “nano-painting”.

Optical image of a nano-printing of Picasso’s “Mediterranean Landscape” (reproduced with permission © Succession Picasso/2022, ProLitteris, Zürich) when using an incorrect polarization key. NAM EPFL

Optical image of a nano-printing of Picasso’s “Mediterranean Landscape” (reproduced with permission © Succession Picasso/2022, ProLitteris, Zürich) when using the correct polarization key. © NAM EPFL

Martin says he believes that the method’s combination of nanotechnology with human visual perception has a lot of potential both for artistic applications and encryption techniques, such as more secure banknotes.

“Nanomaterials and color are at the crossroads of high-tech and artistry, and I find that very appealing. Using nanostructures, you can encode a huge amount of information onto an extremely small area, so there is the potential for very high information density. At the same time, an approach to encryption that can be read and interpreted by the naked human eye, as opposed to a computer, could be advantageous.”

Advanced Optical Materials

Figure 1

Color contrast controlled by polarization. a) Readout principle: each color pixel contains a rectangular Ag nanostructure (scale bar 300 nm). The incident polarization is controlled with a polarizer and the scattered light goes through another polarizer (analyzer). b) Muted colors with low chroma are generated when the polarizer and analyzer are parallel to the nanostructures axis (horizontal polarization). c) When rotating both polarizers perpendicular to the nanostructures axis, all the colors appear greyish (vertical polarization). d) When both polarizers are rotated by 45°, along the diagonal direction, vivid and saturated colors are observed.

Figure 2

Colors controlled by the illumination and detection polarizations. a) Unit cell used in this work, with the nanorod aligned horizontally. b) Titled SEM image of a typical fabricated sample, scale bar 300 nm. c) Computed reflectances
and phases for different combinations of the illumination polarization α and the detection polarization β. Phase shift between the incident and the reflected lights, induced by the sample (see text for details). d) Polarization states of reflected light (red arrows) as a function τ under diagonal polarization illumination (black arrows). e) Computed reflectances for diagonal polarized illumination and four different detection polarizations. f) Measured reflectance for the sample in (b) for different polarization combinations. Panels (c)–(f) are for L = 100 nm.

See the science paper for further illustrations.

See the full article here .

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EPFL campus

The Swiss Federal Institute of Technology in Lausanne [EPFL-École Polytechnique Fédérale de Lausanne] (CH) is a research institute and university in Lausanne, Switzerland, that specializes in natural sciences and engineering. It is one of the two Swiss Federal Institutes of Technology, and it has three main missions: education, research and technology transfer.

The QS World University Rankings ranks EPFL(CH) 14th in the world across all fields in their 2020/2021 ranking, whereas Times Higher Education World University Rankings ranks EPFL(CH) as the world’s 19th best school for Engineering and Technology in 2020.

EPFL(CH) is located in the French-speaking part of Switzerland; the sister institution in the German-speaking part of Switzerland is The Swiss Federal Institute of Technology ETH Zürich [Eidgenössische Technische Hochschule Zürich] (CH). Associated with several specialized research institutes, the two universities form The Domain of the Swiss Federal Institutes of Technology (ETH Domain) [ETH-Bereich; Domaine des Écoles Polytechniques Fédérales] (CH) which is directly dependent on the Federal Department of Economic Affairs, Education and Research. In connection with research and teaching activities, EPFL(CH) operates a nuclear reactor CROCUS; a Tokamak Fusion reactor; a Blue Gene/Q Supercomputer; and P3 bio-hazard facilities.

ETH Zürich, EPFL (Swiss Federal Institute of Technology in Lausanne) [École Polytechnique Fédérale de Lausanne](CH), and four associated research institutes form The Domain of the Swiss Federal Institutes of Technology (ETH Domain) [ETH-Bereich; Domaine des Écoles polytechniques fédérales] (CH) with the aim of collaborating on scientific projects.

The roots of modern-day EPFL(CH) can be traced back to the foundation of a private school under the name École Spéciale de Lausanne in 1853 at the initiative of Lois Rivier, a graduate of the École Centrale Paris (FR) and John Gay the then professor and rector of the Académie de Lausanne. At its inception it had only 11 students and the offices were located at Rue du Valentin in Lausanne. In 1869, it became the technical department of the public Académie de Lausanne. When the Académie was reorganized and acquired the status of a university in 1890, the technical faculty changed its name to École d’Ingénieurs de l’Université de Lausanne. In 1946, it was renamed the École polytechnique de l’Université de Lausanne (EPUL). In 1969, the EPUL was separated from the rest of the University of Lausanne and became a federal institute under its current name. EPFL(CH), like ETH Zürich (CH), is thus directly controlled by the Swiss federal government. In contrast, all other universities in Switzerland are controlled by their respective cantonal governments. Following the nomination of Patrick Aebischer as president in 2000, EPFL(CH) has started to develop into the field of life sciences. It absorbed the Swiss Institute for Experimental Cancer Research (ISREC) in 2008.

In 1946, there were 360 students. In 1969, EPFL(CH) had 1,400 students and 55 professors. In the past two decades the university has grown rapidly and as of 2012 roughly 14,000 people study or work on campus, about 9,300 of these being Bachelor, Master or PhD students. The environment at modern day EPFL(CH) is highly international with the school attracting students and researchers from all over the world. More than 125 countries are represented on the campus and the university has two official languages, French and English.

Organization

EPFL is organized into eight schools, themselves formed of institutes that group research units (laboratories or chairs) around common themes:

School of Basic Sciences
Institute of Mathematics
Institute of Chemical Sciences and Engineering
Institute of Physics
European Centre of Atomic and Molecular Computations
Bernoulli Center
Biomedical Imaging Research Center
Interdisciplinary Center for Electron Microscopy
MPG-EPFL Centre for Molecular Nanosciences and Technology
Swiss Plasma Center
Laboratory of Astrophysics

School of Engineering

Institute of Electrical Engineering
Institute of Mechanical Engineering
Institute of Materials
Institute of Microengineering
Institute of Bioengineering

School of Architecture, Civil and Environmental Engineering

Institute of Architecture
Civil Engineering Institute
Institute of Urban and Regional Sciences
Environmental Engineering Institute

School of Computer and Communication Sciences

Algorithms & Theoretical Computer Science
Artificial Intelligence & Machine Learning
Computational Biology
Computer Architecture & Integrated Systems
Data Management & Information Retrieval
Graphics & Vision
Human-Computer Interaction
Information & Communication Theory
Networking
Programming Languages & Formal Methods
Security & Cryptography
Signal & Image Processing
Systems

School of Life Sciences

Bachelor-Master Teaching Section in Life Sciences and Technologies
Brain Mind Institute
Institute of Bioengineering
Swiss Institute for Experimental Cancer Research
Global Health Institute
Ten Technology Platforms & Core Facilities (PTECH)
Center for Phenogenomics
NCCR Synaptic Bases of Mental Diseases

College of Management of Technology

Swiss Finance Institute at EPFL
Section of Management of Technology and Entrepreneurship
Institute of Technology and Public Policy
Institute of Management of Technology and Entrepreneurship
Section of Financial Engineering

College of Humanities

Human and social sciences teaching program

EPFL Middle East

Section of Energy Management and Sustainability

In addition to the eight schools there are seven closely related institutions

Swiss Cancer Centre
Center for Biomedical Imaging (CIBM)
Centre for Advanced Modelling Science (CADMOS)
École Cantonale d’art de Lausanne (ECAL)
Campus Biotech
Wyss Center for Bio- and Neuro-engineering
Swiss National Supercomputing Centre

From The Cavendish Laboratory – Department of Physics At The University of Cambridge (UK): “Researchers devise a new path toward ‘quantum light’”

From The Cavendish Laboratory – Department of Physics

At

The University of Cambridge (UK)

2.2.23
Sarah Collins
sarah.collins@admin.cam.ac.uk

Credit: David Wall via Getty Images.

Researchers have theorized a new mechanism to generate high-energy ‘quantum light’, which could be used to investigate new properties of matter at the atomic scale.

The researchers, from the University of Cambridge, along with colleagues from the US, Israel and Austria, developed a theory describing a new state of light, which has controllable quantum properties over a broad range of frequencies, up as high as X-ray frequencies. Their results are reported in the journal Nature Physics [below].

The world we observe around us can be described according to the laws of classical physics, but once we observe things at an atomic scale, the strange world of quantum physics takes over. Imagine a basketball: observing it with the naked eye, the basketball behaves according to the laws of classical physics. But the atoms that make up the basketball behave according to quantum physics instead.

“Light is no exception: from sunlight to radio waves, it can mostly be described using classical physics,” said lead author Dr Andrea Pizzi, who carried out the research while based at Cambridge’s Cavendish Laboratory. “But at the micro and nanoscale so-called quantum fluctuations start playing a role and classical physics cannot account for them.”

Pizzi, who is currently based at Harvard University, worked with Ido Kaminer’s group at the Technion-Israel Institute of Technology and colleagues at MIT and the University of Vienna to develop a theory that predicts a new way of controlling the quantum nature of light.

“Quantum fluctuations make quantum light harder to study, but also more interesting: if correctly engineered, quantum fluctuations can be a resource,” said Pizzi. “Controlling the state of quantum light could enable new techniques in microscopy and quantum computation.”

One of the main techniques for generating light uses strong lasers. When a strong enough laser is pointed at a collection of emitters, it can rip some electrons away from the emitters and energize them. Eventually, some of these electrons recombine with the emitters they were extracted from, and the excess energy they absorbed is released as light. This process turns the low-frequency input light into high-frequency output radiation.

“The assumption has been that all these emitters are independent from one another, resulting in output light in which quantum fluctuations are pretty featureless,” said Pizzi. “We wanted to study a system where the emitters are not independent, but correlated: the state of one particle tells you something about the state of another. In this case, the output light starts behaving very differently, and its quantum fluctuations become highly structured, and potentially more useful.”

To solve this type of problem, known as a many body problem, the researchers used a combination of theoretical analysis and computer simulations, where the output light from a group of correlated emitters could be described using quantum physics.

The theory, whose development was led by Pizzi and Alexey Gorlach from the Technion, demonstrates that controllable quantum light can be generated by correlated emitters with a strong laser. The method generates high-energy output light, and could be used to engineer the quantum-optical structure of X-rays.

“We worked for months to get the equations cleaner and cleaner until we got to the point where we could describe the connection between the output light and the input correlations with just one compact equation. As a physicist, I find this beautiful,” said Pizzi. “Looking forward, we would like to collaborate with experimentalists to provide a validation of our predictions. On the theory side of things, our work suggests many-body systems as a resource for generating quantum light, a concept that we want to investigate more broadly, beyond the setup considered in this work.”

The research was supported in part by the Royal Society. Andrea Pizzi is a Junior Research Fellow at Trinity College, Cambridge.

Nature Physics

See the full article here .

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The Cavendish Laboratory is the Department of Physics at the University of Cambridge, and is part of the School of Physical Sciences. The laboratory was opened in 1874 on the New Museums Site as a laboratory for experimental physics and is named after the British chemist and physicist Henry Cavendish. The laboratory has had a huge influence on research in the disciplines of physics and biology.

As of 2019, 30 Cavendish researchers have won Nobel Prizes. Notable discoveries to have occurred at the Cavendish Laboratory include the discovery of the electron, neutron, and structure of DNA.

The Cavendish Laboratory was initially located on the New Museums Site, Free School Lane, in the centre of Cambridge. It is named after British chemist and physicist Henry Cavendish for contributions to science and his relative William Cavendish, 7th Duke of Devonshire, who served as chancellor of the university and donated funds for the construction of the laboratory.

Professor James Clerk Maxwell, the developer of electromagnetic theory, was a founder of the laboratory and the first Cavendish Professor of Physics. The Duke of Devonshire had given to Maxwell, as head of the laboratory, the manuscripts of Henry Cavendish’s unpublished Electrical Works. The editing and publishing of these was Maxwell’s main scientific work while he was at the laboratory. Cavendish’s work aroused Maxwell’s intense admiration and he decided to call the Laboratory (formerly known as the Devonshire Laboratory) the Cavendish Laboratory and thus to commemorate both the Duke and Henry Cavendish.

Physics

Several important early physics discoveries were made here, including the discovery of the electron by J.J. Thomson (1897); the Townsend discharge by John Sealy Townsend and the development of the cloud chamber by C.T.R. Wilson.

Ernest Rutherford became Director of the Cavendish Laboratory in 1919. Under his leadership the neutron was discovered by James Chadwick in 1932, and in the same year the first experiment to split the nucleus in a fully controlled manner was performed by students working under his direction; John Cockcroft and Ernest Walton.

Physical chemistry

Physical Chemistry (originally the department of Colloid Science led by Eric Rideal) had left the old Cavendish site, subsequently locating as the Department of Physical Chemistry (under RG Norrish) in the then new chemistry building with the Department of Chemistry (led by Lord Todd) in Lensfield Road: both chemistry departments merged in the 1980s.

Nuclear physics

In World War II the laboratory carried out research for the MAUD Committee, part of the British Tube Alloys project of research into the atomic bomb. Researchers included Nicholas Kemmer, Alan Nunn May, Anthony French, Samuel Curran and the French scientists including Lew Kowarski and Hans von Halban. Several transferred to Canada in 1943; the Montreal Laboratory and some later to the Chalk River Laboratories. The production of plutonium and neptunium by bombarding uranium-238 with neutrons was predicted in 1940 by two teams working independently: Egon Bretscher and Norman Feather at the Cavendish and Edwin M. McMillan and Philip Abelson at Berkeley Radiation Laboratory at The University of California-Berkeley.

Biology

The Cavendish Laboratory has had an important influence on biology, mainly through the application of X-ray crystallography to the study of structures of biological molecules. Francis Crick already worked in the Medical Research Council Unit, headed by Max Perutz and housed in the Cavendish Laboratory, when James Watson came from the United States and they made a breakthrough in discovering the structure of DNA. For their work while in the Cavendish Laboratory, they were jointly awarded the Nobel Prize in Physiology or Medicine in 1962, together with Maurice Wilkins of King’s College London (UK), himself a graduate of St. John’s College, Cambridge.

The discovery was made on 28 February 1953; the first Watson/Crick paper appeared in Nature on 25 April 1953. Sir Lawrence Bragg, the director of the Cavendish Laboratory, where Watson and Crick worked, gave a talk at Guy’s Hospital Medical School in London on Thursday 14 May 1953 which resulted in an article by Ritchie Calder in The News Chronicle of London, on Friday 15 May 1953, entitled Why You Are You. Nearer Secret of Life. The news reached readers of The New York Times the next day; Victor K. McElheny, in researching his biography, Watson and DNA: Making a Scientific Revolution, found a clipping of a six-paragraph New York Times article written from London and dated 16 May 1953 with the headline Form of `Life Unit’ in Cell Is Scanned. The article ran in an early edition and was then pulled to make space for news deemed more important. (The New York Times subsequently ran a longer article on 12 June 1953). The Cambridge University undergraduate newspaper Varsity also ran its own short article on the discovery on Saturday 30 May 1953. Bragg’s original announcement of the discovery at a Solvay Conference on proteins in Belgium on 8 April 1953 went unreported by the British press.

Sydney Brenner, Jack Dunitz, Dorothy Hodgkin, Leslie Orgel, and Beryl M. Oughton, were some of the first people in April 1953 to see the model of the structure of DNA, constructed by Crick and Watson; at the time they were working at The University of Oxford (UK)’s Chemistry Department. All were impressed by the new DNA model, especially Brenner who subsequently worked with Crick at Cambridge in the Cavendish Laboratory and the new Laboratory of Molecular Biology. According to the late Dr. Beryl Oughton, later Rimmer, they all travelled together in two cars once Dorothy Hodgkin announced to them that they were off to Cambridge to see the model of the structure of DNA. Orgel also later worked with Crick at The Salk Institute for Biological Studies.

The University of Cambridge (UK) [legally The Chancellor, Masters, and Scholars of the University of Cambridge] is a collegiate public research university in Cambridge, England. Founded in 1209 Cambridge is the second-oldest university in the English-speaking world and the world’s fourth-oldest surviving university. It grew out of an association of scholars who left the University of Oxford(UK) after a dispute with townsfolk. The two ancient universities share many common features and are often jointly referred to as “Oxbridge”.

Cambridge is formed from a variety of institutions which include 31 semi-autonomous constituent colleges and over 150 academic departments, faculties and other institutions organised into six schools. All the colleges are self-governing institutions within the university, each controlling its own membership and with its own internal structure and activities. All students are members of a college. Cambridge does not have a main campus and its colleges and central facilities are scattered throughout the city. Undergraduate teaching at Cambridge is organised around weekly small-group supervisions in the colleges – a feature unique to the Oxbridge system. These are complemented by classes, lectures, seminars, laboratory work and occasionally further supervisions provided by the central university faculties and departments. Postgraduate teaching is provided predominantly centrally.

Cambridge University Press a department of the university is the oldest university press in the world and currently the second largest university press in the world. Cambridge Assessment also a department of the university is one of the world’s leading examining bodies and provides assessment to over eight million learners globally every year. The university also operates eight cultural and scientific museums, including the Fitzwilliam Museum, as well as a botanic garden. Cambridge’s libraries – of which there are 116 – hold a total of around 16 million books, around nine million of which are in Cambridge University Library, a legal deposit library. The university is home to – but independent of – the Cambridge Union – the world’s oldest debating society. The university is closely linked to the development of the high-tech business cluster known as “Silicon Fe”. It is the central member of Cambridge University Health Partners, an academic health science centre based around the Cambridge Biomedical Campus.

By both endowment size and consolidated assets Cambridge is the wealthiest university in the United Kingdom. In the fiscal year ending 31 July 2019, the central university – excluding colleges – had a total income of £2.192 billion of which £592.4 million was from research grants and contracts. At the end of the same financial year the central university and colleges together possessed a combined endowment of over £7.1 billion and overall consolidated net assets (excluding “immaterial” historical assets) of over £12.5 billion. It is a member of numerous associations and forms part of the ‘golden triangle’ of English universities.

Cambridge has educated many notable alumni including eminent mathematicians; scientists; politicians; lawyers; philosophers; writers; actors; monarchs and other heads of state. As of October 2020 121 Nobel laureates; 11 Fields Medalists; 7 Turing Award winners; and 14 British prime ministers have been affiliated with Cambridge as students; alumni; faculty or research staff. University alumni have won 194 Olympic medals.

History

By the late 12th century the Cambridge area already had a scholarly and ecclesiastical reputation due to monks from the nearby bishopric church of Ely. However it was an incident at Oxford which is most likely to have led to the establishment of the university: three Oxford scholars were hanged by the town authorities for the death of a woman without consulting the ecclesiastical authorities who would normally take precedence (and pardon the scholars) in such a case; but were at that time in conflict with King John. Fearing more violence from the townsfolk scholars from the University of Oxford started to move away to cities such as Paris; Reading; and Cambridge. Subsequently enough scholars remained in Cambridge to form the nucleus of a new university when it had become safe enough for academia to resume at Oxford. In order to claim precedence it is common for Cambridge to trace its founding to the 1231 charter from Henry III granting it the right to discipline its own members (ius non-trahi extra) and an exemption from some taxes; Oxford was not granted similar rights until 1248.

A bull in 1233 from Pope Gregory IX gave graduates from Cambridge the right to teach “everywhere in Christendom”. After Cambridge was described as a studium generale in a letter from Pope Nicholas IV in 1290 and confirmed as such in a bull by Pope John XXII in 1318 it became common for researchers from other European medieval universities to visit Cambridge to study or to give lecture courses.

Foundation of the colleges

The colleges at the University of Cambridge were originally an incidental feature of the system. No college is as old as the university itself. The colleges were endowed fellowships of scholars. There were also institutions without endowments called hostels. The hostels were gradually absorbed by the colleges over the centuries; but they have left some traces, such as the name of Garret Hostel Lane.

Hugh Balsham, Bishop of Ely, founded Peterhouse – Cambridge’s first college in 1284. Many colleges were founded during the 14th and 15th centuries but colleges continued to be established until modern times. There was a gap of 204 years between the founding of Sidney Sussex in 1596 and that of Downing in 1800. The most recently established college is Robinson built in the late 1970s. However Homerton College only achieved full university college status in March 2010 making it the newest full college (it was previously an “Approved Society” affiliated with the university).

In medieval times many colleges were founded so that their members would pray for the souls of the founders and were often associated with chapels or abbeys. The colleges’ focus changed in 1536 with the Dissolution of the Monasteries. Henry VIII ordered the university to disband its Faculty of Canon Law and to stop teaching “scholastic philosophy”. In response, colleges changed their curricula away from canon law and towards the classics; the Bible; and mathematics.

Nearly a century later the university was at the centre of a Protestant schism. Many nobles, intellectuals and even commoners saw the ways of the Church of England as too similar to the Catholic Church and felt that it was used by the Crown to usurp the rightful powers of the counties. East Anglia was the centre of what became the Puritan movement. In Cambridge the movement was particularly strong at Emmanuel; St Catharine’s Hall; Sidney Sussex; and Christ’s College. They produced many “non-conformist” graduates who, greatly influenced by social position or preaching left for New England and especially the Massachusetts Bay Colony during the Great Migration decade of the 1630s. Oliver Cromwell, Parliamentary commander during the English Civil War and head of the English Commonwealth (1649–1660), attended Sidney Sussex.

Modern period

After the Cambridge University Act formalised the organisational structure of the university the study of many new subjects was introduced e.g. theology, history and modern languages. Resources necessary for new courses in the arts architecture and archaeology were donated by Viscount Fitzwilliam of Trinity College who also founded the Fitzwilliam Museum. In 1847 Prince Albert was elected Chancellor of the University of Cambridge after a close contest with the Earl of Powis. Albert used his position as Chancellor to campaign successfully for reformed and more modern university curricula, expanding the subjects taught beyond the traditional mathematics and classics to include modern history and the natural sciences. Between 1896 and 1902 Downing College sold part of its land to build the Downing Site with new scientific laboratories for anatomy, genetics, and Earth sciences. During the same period the New Museums Site was erected including the Cavendish Laboratory which has since moved to the West Cambridge Site and other departments for chemistry and medicine.

The University of Cambridge began to award PhD degrees in the first third of the 20th century. The first Cambridge PhD in mathematics was awarded in 1924.

In the First World War 13,878 members of the university served and 2,470 were killed. Teaching and the fees it earned came almost to a stop and severe financial difficulties followed. As a consequence the university first received systematic state support in 1919 and a Royal Commission appointed in 1920 recommended that the university (but not the colleges) should receive an annual grant. Following the Second World War the university saw a rapid expansion of student numbers and available places; this was partly due to the success and popularity gained by many Cambridge scientists.

From The Massachusetts Institute of Technology: “Engineers invent vertical full-color microscopic LEDs”

From The Massachusetts Institute of Technology

2.1.23
Jennifer Chu

MIT engineers have developed a new way to make sharper, defect-free displays. Instead of patterning red, green, and blue diodes side by side in a horizontal patchwork, the team has invented a way to stack the diodes to create vertical, multicolored pixels. Image: Illustration by Younghee Lee.

Take apart your laptop screen, and at its heart you’ll find a plate patterned with pixels of red, green, and blue LEDs, arranged end to end like a meticulous Lite Brite display. When electrically powered, the LEDs together can produce every shade in the rainbow to generate full-color displays. Over the years, the size of individual pixels has shrunk, enabling many more of them to be packed into devices to produce sharper, higher-resolution digital displays.

But much like computer transistors, LEDs are reaching a limit to how small they can be while also performing effectively. This limit is especially noticeable in close-range displays such as augmented and virtual reality devices, where limited pixel density results in a “screen door effect” such that users perceive stripes in the space between pixels.

Now, MIT engineers have developed a new way to make sharper, defect-free displays. Instead of replacing red, green, and blue light-emitting diodes side by side in a horizontal patchwork, the team has invented a way to stack the diodes to create vertical, multicolored pixels.

Each stacked pixel can generate the full commercial range of colors and measures about 4 microns wide. The microscopic pixels, or “micro-LEDs,” can be packed to a density of 5,000 pixels per inch.

“This is the smallest micro-LED pixel, and the highest pixel density reported in the journals,” says Jeehwan Kim, associate professor of mechanical engineering at MIT. “We show that vertical pixellation is the way to go for higher-resolution displays in a smaller footprint.”

“For virtual reality, right now there is a limit to how real they can look,” adds Jiho Shin, a postdoc in Kim’s research group. “With our vertical micro-LEDs, you could have a completely immersive experience and wouldn’t be able to distinguish virtual from reality.”

The team’s results are published today in the journal Nature [below]. Kim and Shin’s co-authors include members of Kim’s lab, researchers around MIT, and collaborators from Georgia Tech Europe, Sejong University, and multiple universities in the U.S, France, and Korea.

Placing pixels

Today’s digital displays are lit through organic light-emitting diodes (OLEDs) — plastic diodes that emit light in response to an electric current. OLEDs are the leading digital display technology, but the diodes can degrade over time, resulting in permanent burn-in effects on screens. The technology is also reaching a limit to the size the diodes can be shrunk, limiting their sharpness and resolution.

For next-generation display technology, researchers are exploring inorganic micro-LEDs — diodes that are one-hundredth the size of conventional LEDs and are made from inorganic, single-crystalline semiconducting materials. Micro-LEDs could perform better, require less energy, and last longer than OLEDs.

But micro-LED fabrication requires extreme accuracy, as microscopic pixels of red, green, and blue need to first be grown separately on wafers, then precisely placed on a plate, in exact alignment with each other in order to properly reflect and produce various colors and shades. Achieving such microscopic precision is a difficult task, and entire devices need to be scrapped if pixels are found to be out of place.

“This pick-and-place fabrication is very likely to misalign pixels in a very small scale,” Kim says. “If you have a misalignment, you have to throw that material away, otherwise it could ruin a display.”

Color stack

The MIT team has come up with a potentially less wasteful way to fabricate micro-LEDs that doesn’t require precise, pixel-by-pixel alignment. The technique is an entirely different, vertical LED approach, in contrast to the conventional, horizontal pixel arrangement.

Kim’s group specializes in developing techniques to fabricate pure, ultrathin, high-performance membranes, with a view toward engineering smaller, thinner, more flexible and functional electronics. The team previously developed a method to grow and peel away perfect, two-dimensional, single-crystalline material from wafers of silicon and other surfaces — an approach they call 2D material-based layer transfer, or 2DLT.

In the current study, the researchers employed this same approach to grow ultrathin membranes of red, green, and blue LEDs. They then peeled the entire LED membranes away from their base wafers, and stacked them together to make a layer cake of red, green, and blue membranes. They could then carve the cake into patterns of tiny, vertical pixels, each as small as 4 microns wide.

“In conventional displays, each R, G, and B pixel is arranged laterally, which limits how small you can create each pixel,” Shin notes. “Because we are stacking all three pixels vertically, in theory we could reduce the pixel area by a third.”

As a demonstration, the team fabricated a vertical LED pixel, and showed that by altering the voltage applied to each of the pixel’s red, green, and blue membranes, they could produce various colors in a single pixel.

“If you have a higher current to red, and weaker to blue, the pixel would appear pink, and so on,” Shin says. “We’re able to create all the mixed colors, and our display can cover close to the commercial color space that’s available.”

The team plans to improve the operation of the vertical pixels. So far, they have shown they can stimulate an individual structure to produce the full spectrum of colors. They will work toward making an array of many vertical micro-LED pixels.

“You need a system to control 25 million LEDs separately,” Shin says. “Here, we’ve only partially demonstrated that. The active matrix operation is something we’ll need to further develop.”

“For now, we have shown to the community that we can grow, peel, and stack ultrathin LEDs,” Kim says. “This is the ultimate solution for small displays like smart watches and virtual reality devices, where you would want highly densified pixels to make lively, vivid images.”

This research was supported, in part, by the U.S. National Science Foundation, the U.S. Defense Advanced Research Projects Agency (DARPA), the U.S. Air Force Research Laboratory, the U.S. Department of Energy, LG Electronics, Rohm Semiconductor, the French National Research Agency, and the National Research Foundation in Korea.

Nature

See the full article here .

Comments are invited and will be appreciated, especially if the reader finds any errors which I can correct. Use “Reply”.

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USPS “Forever” postage stamps celebrating Innovation at MIT.

The Massachusetts Institute of Technology is a private land-grant research university in Cambridge, Massachusetts. The institute has an urban campus that extends more than a mile (1.6 km) alongside the Charles River. The institute also encompasses a number of major off-campus facilities such as the MIT Lincoln Laboratory , the MIT Bates Research and Engineering Center , and the Haystack Observatory , as well as affiliated laboratories such as the Broad Institute of MIT and Harvard and Whitehead Institute.

MIT AeroAstro campus

MIT Lincoln Laboratory campus

Massachusettes Institute of Technology-Haystack Observatory Westford, Massachusetts, USA, Altitude 131 m (430 ft).

The Computer Science and Artificial Intelligence Laboratory (CSAIL)

MIT-IBM Watson AI Lab, 314 Main St. in the Kendall Square technology center of Cambridge, Massachusetts.

From The Kavli Institute For Astrophysics and Space Research

MIT’s Institute for Medical Engineering and Science is a research institute at the Massachusetts Institute of Technology

The MIT Laboratory for Nuclear Science

The MIT Media Lab

MIT PLasma Science and Fusion Center

The MIT School of Engineering

The MIT Sloan School of Management

Spectrum

MIT School of Architecture and Planning campus.

MIT Electrical Engineering & Computer Science campus.

Founded in 1861 in response to the increasing industrialization of the United States, Massachusetts Institute of Technology adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. It has since played a key role in the development of many aspects of modern science, engineering, mathematics, and technology, and is widely known for its innovation and academic strength. It is frequently regarded as one of the most prestigious universities in the world.

As of December 2020, 97 Nobel laureates, 26 Turing Award winners, and 8 Fields Medalists have been affiliated with MIT as alumni, faculty members, or researchers. In addition, 58 National Medal of Science recipients, 29 National Medals of Technology and Innovation recipients, 50 MacArthur Fellows, 80 Marshall Scholars, 3 Mitchell Scholars, 22 Schwarzman Scholars, 41 astronauts, and 16 Chief Scientists of the U.S. Air Force have been affiliated with The Massachusetts Institute of Technology. The university also has a strong entrepreneurial culture and MIT alumni have founded or co-founded many notable companies. Massachusetts Institute of Technology is a member of the Association of American Universities.

Foundation and vision

In 1859, a proposal was submitted to the Massachusetts General Court to use newly filled lands in Back Bay, Boston for a “Conservatory of Art and Science”, but the proposal failed. A charter for the incorporation of the Massachusetts Institute of Technology, proposed by William Barton Rogers, was signed by John Albion Andrew, the governor of Massachusetts, on April 10, 1861.

Rogers, a professor from the University of Virginia , wanted to establish an institution to address rapid scientific and technological advances. He did not wish to found a professional school, but a combination with elements of both professional and liberal education, proposing that:

“The true and only practicable object of a polytechnic school is, as I conceive, the teaching, not of the minute details and manipulations of the arts, which can be done only in the workshop, but the inculcation of those scientific principles which form the basis and explanation of them, and along with this, a full and methodical review of all their leading processes and operations in connection with physical laws.”

The Rogers Plan reflected the German research university model, emphasizing an independent faculty engaged in research, as well as instruction oriented around seminars and laboratories.

Early developments

Two days after The Massachusetts Institute of Technology was chartered, the first battle of the Civil War broke out. After a long delay through the war years, MIT’s first classes were held in the Mercantile Building in Boston in 1865. The new institute was founded as part of the Morrill Land-Grant Colleges Act to fund institutions “to promote the liberal and practical education of the industrial classes” and was a land-grant school. In 1863 under the same act, the Commonwealth of Massachusetts founded the Massachusetts Agricultural College, which developed as the University of Massachusetts Amherst ). In 1866, the proceeds from land sales went toward new buildings in the Back Bay.

The Massachusetts Institute of Technology was informally called “Boston Tech”. The institute adopted the European polytechnic university model and emphasized laboratory instruction from an early date. Despite chronic financial problems, the institute saw growth in the last two decades of the 19th century under President Francis Amasa Walker. Programs in electrical, chemical, marine, and sanitary engineering were introduced, new buildings were built, and the size of the student body increased to more than one thousand.

The curriculum drifted to a vocational emphasis, with less focus on theoretical science. The fledgling school still suffered from chronic financial shortages which diverted the attention of the MIT leadership. During these “Boston Tech” years, Massachusetts Institute of Technology faculty and alumni rebuffed Harvard University president (and former MIT faculty) Charles W. Eliot’s repeated attempts to merge MIT with Harvard College’s Lawrence Scientific School. There would be at least six attempts to absorb MIT into Harvard. In its cramped Back Bay location, MIT could not afford to expand its overcrowded facilities, driving a desperate search for a new campus and funding. Eventually, the MIT Corporation approved a formal agreement to merge with Harvard, over the vehement objections of MIT faculty, students, and alumni. However, a 1917 decision by the Massachusetts Supreme Judicial Court effectively put an end to the merger scheme.

In 1916, The Massachusetts Institute of Technology administration and the MIT charter crossed the Charles River on the ceremonial barge Bucentaur built for the occasion, to signify MIT’s move to a spacious new campus largely consisting of filled land on a one-mile-long (1.6 km) tract along the Cambridge side of the Charles River. The neoclassical “New Technology” campus was designed by William W. Bosworth and had been funded largely by anonymous donations from a mysterious “Mr. Smith”, starting in 1912. In January 1920, the donor was revealed to be the industrialist George Eastman of Rochester, New York, who had invented methods of film production and processing, and founded Eastman Kodak. Between 1912 and 1920, Eastman donated $20 million ($236.6 million in 2015 dollars) in cash and Kodak stock to MIT.

Curricular reforms

In the 1930s, President Karl Taylor Compton and Vice-President (effectively Provost) Vannevar Bush emphasized the importance of pure sciences like physics and chemistry and reduced the vocational practice required in shops and drafting studios. The Compton reforms “renewed confidence in the ability of the Institute to develop leadership in science as well as in engineering”. Unlike Ivy League schools, Massachusetts Institute of Technology catered more to middle-class families, and depended more on tuition than on endowments or grants for its funding. The school was elected to the Association of American Universities in 1934.

Still, as late as 1949, the Lewis Committee lamented in its report on the state of education at The Massachusetts Institute of Technology that “the Institute is widely conceived as basically a vocational school”, a “partly unjustified” perception the committee sought to change. The report comprehensively reviewed the undergraduate curriculum, recommended offering a broader education, and warned against letting engineering and government-sponsored research detract from the sciences and humanities. The School of Humanities, Arts, and Social Sciences and the MIT Sloan School of Management were formed in 1950 to compete with the powerful Schools of Science and Engineering. Previously marginalized faculties in the areas of economics, management, political science, and linguistics emerged into cohesive and assertive departments by attracting respected professors and launching competitive graduate programs. The School of Humanities, Arts, and Social Sciences continued to develop under the successive terms of the more humanistically oriented presidents Howard W. Johnson and Jerome Wiesner between 1966 and 1980.

The Massachusetts Institute of Technology‘s involvement in military science surged during World War II. In 1941, Vannevar Bush was appointed head of the federal Office of Scientific Research and Development and directed funding to only a select group of universities, including MIT. Engineers and scientists from across the country gathered at Massachusetts Institute of Technology ‘s Radiation Laboratory, established in 1940 to assist the British military in developing microwave radar. The work done there significantly affected both the war and subsequent research in the area. Other defense projects included gyroscope-based and other complex control systems for gunsight, bombsight, and inertial navigation under Charles Stark Draper’s Instrumentation Laboratory; the development of a digital computer for flight simulations under Project Whirlwind; and high-speed and high-altitude photography under Harold Edgerton. By the end of the war, The Massachusetts Institute of Technology became the nation’s largest wartime R&D contractor (attracting some criticism of Bush), employing nearly 4000 in the Radiation Laboratory alone and receiving in excess of $100 million ($1.2 billion in 2015 dollars) before 1946. Work on defense projects continued even after then. Post-war government-sponsored research at MIT included SAGE and guidance systems for ballistic missiles and Project Apollo.

These activities affected The Massachusetts Institute of Technology profoundly. A 1949 report noted the lack of “any great slackening in the pace of life at the Institute” to match the return to peacetime, remembering the “academic tranquility of the prewar years”, though acknowledging the significant contributions of military research to the increased emphasis on graduate education and rapid growth of personnel and facilities. The faculty doubled and the graduate student body quintupled during the terms of Karl Taylor Compton, president of The Massachusetts Institute of Technology between 1930 and 1948; James Rhyne Killian, president from 1948 to 1957; and Julius Adams Stratton, chancellor from 1952 to 1957, whose institution-building strategies shaped the expanding university. By the 1950s, The Massachusetts Institute of Technology no longer simply benefited the industries with which it had worked for three decades, and it had developed closer working relationships with new patrons, philanthropic foundations and the federal government.

In late 1960s and early 1970s, student and faculty activists protested against the Vietnam War and The Massachusetts Institute of Technology ‘s defense research. In this period Massachusetts Institute of Technology’s various departments were researching helicopters, smart bombs and counterinsurgency techniques for the war in Vietnam as well as guidance systems for nuclear missiles. The Union of Concerned Scientists was founded on March 4, 1969 during a meeting of faculty members and students seeking to shift the emphasis on military research toward environmental and social problems. The Massachusetts Institute of Technology ultimately divested itself from the Instrumentation Laboratory and moved all classified research off-campus to the MIT Lincoln Laboratory facility in 1973 in response to the protests. The student body, faculty, and administration remained comparatively unpolarized during what was a tumultuous time for many other universities. Johnson was seen to be highly successful in leading his institution to “greater strength and unity” after these times of turmoil. However, six Massachusetts Institute of Technology students were sentenced to prison terms at this time and some former student leaders, such as Michael Albert and George Katsiaficas, are still indignant about MIT’s role in military research and its suppression of these protests. (Richard Leacock’s film, November Actions, records some of these tumultuous events.)

In the 1980s, there was more controversy at The Massachusetts Institute of Technology over its involvement in SDI (space weaponry) and CBW (chemical and biological warfare) research. More recently, The Massachusetts Institute of Technology’s research for the military has included work on robots, drones and ‘battle suits’.

Recent history

The Massachusetts Institute of Technology has kept pace with and helped to advance the digital age. In addition to developing the predecessors to modern computing and networking technologies, students, staff, and faculty members at Project MAC, the Artificial Intelligence Laboratory, and the Tech Model Railroad Club wrote some of the earliest interactive computer video games like Spacewar! and created much of modern hacker slang and culture. Several major computer-related organizations have originated at MIT since the 1980s: Richard Stallman’s GNU Project and the subsequent Free Software Foundation were founded in the mid-1980s at the AI Lab; the MIT Media Lab was founded in 1985 by Nicholas Negroponte and Jerome Wiesner to promote research into novel uses of computer technology; the World Wide Web Consortium standards organization was founded at the Laboratory for Computer Science in 1994 by Tim Berners-Lee; the MIT OpenCourseWare project has made course materials for over 2,000 Massachusetts Institute of Technology classes available online free of charge since 2002; and the One Laptop per Child initiative to expand computer education and connectivity to children worldwide was launched in 2005.

The Massachusetts Institute of Technology was named a sea-grant college in 1976 to support its programs in oceanography and marine sciences and was named a space-grant college in 1989 to support its aeronautics and astronautics programs. Despite diminishing government financial support over the past quarter century, MIT launched several successful development campaigns to significantly expand the campus: new dormitories and athletics buildings on west campus; the Tang Center for Management Education; several buildings in the northeast corner of campus supporting research into biology, brain and cognitive sciences, genomics, biotechnology, and cancer research; and a number of new “backlot” buildings on Vassar Street including the Stata Center. Construction on campus in the 2000s included expansions of the Media Lab, the Sloan School’s eastern campus, and graduate residences in the northwest. In 2006, President Hockfield launched the MIT Energy Research Council to investigate the interdisciplinary challenges posed by increasing global energy consumption.

In 2001, inspired by the open source and open access movements, The Massachusetts Institute of Technology launched “OpenCourseWare” to make the lecture notes, problem sets, syllabi, exams, and lectures from the great majority of its courses available online for no charge, though without any formal accreditation for coursework completed. While the cost of supporting and hosting the project is high, OCW expanded in 2005 to include other universities as a part of the OpenCourseWare Consortium, which currently includes more than 250 academic institutions with content available in at least six languages. In 2011, The Massachusetts Institute of Technology announced it would offer formal certification (but not credits or degrees) to online participants completing coursework in its “MITx” program, for a modest fee. The “edX” online platform supporting MITx was initially developed in partnership with Harvard and its analogous “Harvardx” initiative. The courseware platform is open source, and other universities have already joined and added their own course content. In March 2009 the Massachusetts Institute of Technology faculty adopted an open-access policy to make its scholarship publicly accessible online.

The Massachusetts Institute of Technology has its own police force. Three days after the Boston Marathon bombing of April 2013, MIT Police patrol officer Sean Collier was fatally shot by the suspects Dzhokhar and Tamerlan Tsarnaev, setting off a violent manhunt that shut down the campus and much of the Boston metropolitan area for a day. One week later, Collier’s memorial service was attended by more than 10,000 people, in a ceremony hosted by the Massachusetts Institute of Technology community with thousands of police officers from the New England region and Canada. On November 25, 2013, The Massachusetts Institute of Technology announced the creation of the Collier Medal, to be awarded annually to “an individual or group that embodies the character and qualities that Officer Collier exhibited as a member of The Massachusetts Institute of Technology community and in all aspects of his life”. The announcement further stated that “Future recipients of the award will include those whose contributions exceed the boundaries of their profession, those who have contributed to building bridges across the community, and those who consistently and selflessly perform acts of kindness”.

In September 2017, the school announced the creation of an artificial intelligence research lab called the MIT-IBM Watson AI Lab. IBM will spend $240 million over the next decade, and the lab will be staffed by MIT and IBM scientists. In October 2018 MIT announced that it would open a new Schwarzman College of Computing dedicated to the study of artificial intelligence, named after lead donor and The Blackstone Group CEO Stephen Schwarzman. The focus of the new college is to study not just AI, but interdisciplinary AI education, and how AI can be used in fields as diverse as history and biology. The cost of buildings and new faculty for the new college is expected to be $1 billion upon completion.

The Caltech/MIT Advanced aLIGO was designed and constructed by a team of scientists from California Institute of Technology , Massachusetts Institute of Technology, and industrial contractors, and funded by the National Science Foundation .

Caltech /MIT Advanced aLigo

It was designed to open the field of gravitational-wave astronomy through the detection of gravitational waves predicted by general relativity. Gravitational waves were detected for the first time by the LIGO detector in 2015. For contributions to the LIGO detector and the observation of gravitational waves, two Caltech physicists, Kip Thorne and Barry Barish, and Massachusetts Institute of Technology physicist Rainer Weiss won the Nobel Prize in physics in 2017. Weiss, who is also a Massachusetts Institute of Technology graduate, designed the laser interferometric technique, which served as the essential blueprint for the LIGO.

The mission of The Massachusetts Institute of Technology is to advance knowledge and educate students in science, technology, and other areas of scholarship that will best serve the nation and the world in the twenty-first century. We seek to develop in each member of The Massachusetts Institute of Technology community the ability and passion to work wisely, creatively, and effectively for the betterment of humankind.

From Colorado State University Via “phys.org” : “Researchers propose combining classical and quantum optics for super-resolution imaging”

From Colorado State University

Via

“phys.org”

1.25.23
Anne Manning

Conceptual rendering of the experiment showing a spatiotemporally modulated optical illumination by a sparse set of mutually coherent beams. Beam interference produces the spatially structured illumination as illustrated in the main figure and insets (A) and (B). A large focal volume is achieved because each beam encompasses a small region of spatial frequency support in the pupil plane. The center spatial frequency of the beams scans across the pupil, cycling through a set of complex illumination patterns with spatial frequency structure the samples the full numerical aperture (NA) of the illumination objective lens throughout the full temporal modulation cycle. The figure shows an unfolded microscope; however, epi detection is possible. Detection efficiency could be improved by combining photon coincidence counts in multiple directions. (A) A zoomed-in example of the structured illumination light intensity at 1 time sample. The specimen is placed in the region of the slide. (B) The spatial structure of the illumination intensity in the plane of the slide for 2 time points. (C) Examples of generalized HBT detection showing cases of 2 and 3 simultaneous photon detection events. Credit: Intelligent Computing (2022)

The ability to see invisible structures in our bodies, like the inner workings of cells, or the aggregation of proteins, depends on the quality of one’s microscope. Ever since the first optical microscopes were invented in the 17th century, scientists have pushed for new ways to see more things more clearly, at smaller scales and deeper depths.

Randy Bartels, professor in the Department of Electrical Engineering at Colorado State University, is one of those scientists. He and a team of researchers at CSU and Colorado School of Mines are on a quest to invent some of the world’s most powerful light microscopes—ones that can resolve large swaths of biological material in unimaginable detail.

The name of the game is “super–resolution microscopy”, which is any optical imaging technique that can resolve things smaller than half the wavelength of light. The discipline was the subject of the 2014 Nobel Prize in Chemistry, and Bartels and others are in a race to keep circumventing that diffraction limit to illuminate biologically important structures inside the body.

Bartels, together with Jeff Squier, a professor of physics at Colorado School of Mines, have theorized a new super–resolution technique that uniquely fuses quantum and classical information derived from light to drastically improve imaging resolution. The math and physics behind their idea, and why they think it will work, is detailed in the journal Intelligent Computing [below]. The paper includes Jeff Field, former director of CSU’s Center for Imaging and Surface Science, as co-author.

Counting photons

Their new computational imaging method works by precisely counting the arrival of photons, or quantum particles of light, emitted from a biological sample. The photons are excited by laser pulses, and by counting them one by one with detectors, a set of quantum and classical images emerge. The researchers then apply an algorithm to produce images that resolve the details of small structures, like cells, over large regions.

“Right now, people can do very high-resolution optical imaging, but it’s kind of like flying over the Rocky Mountains and being able to see all the trees, but not the fine details of the trees,” explained Bartels. Other super–resolution techniques exist that allow someone to zoom way in, say, on an individual leaf, he continued. But to look in fine detail across an entire forest is what Bartels and the team are going for.

“The idea here is to illuminate a large region of many cells, at high resolution, high speed, and across a high volume,” Bartels said.

Bartels has worked with Mines’ Squier for several years. Their research partnership combines Bartels’ expertise in computation with Squier’s expertise in optical engineering, creating custom optics for their shared goals.

“While our paper represents a fusion of classical and quantum physics, it is fair to say it also represents a fusion of ideas from both Mines and CSU,” Squier said. “The fundamental ideas in the paper simply would not have manifested without the close collaboration that has been built up over the past several years by our groups.”

Intelligent Computing
See the science paper for instructive material with images.

See the full article here .

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From Colorado State University is a public research university in the U.S. state of Colorado. The university is the state’s land grant university, and the flagship university of the Colorado State University System.

The current enrollment is approximately 37,198 students, including resident and non-resident instruction students and the University is planning on having 42,000 students by 2020. The university has approximately 2,000 faculty in eight colleges and 55 academic departments. Bachelor’s degrees are offered in 65 fields of study, with master’s degrees in 55 fields. Colorado State confers doctoral degrees in 40 fields of study, in addition to a professional degree in veterinary medicine.

From The Swiss Federal Institute of Technology in Lausanne [EPFL-École Polytechnique Fédérale de Lausanne] (CH): “Integrated photonic circuits could help close the ‘terahertz gap'”

From The Swiss Federal Institute of Technology in Lausanne [EPFL-École Polytechnique Fédérale de Lausanne] (CH)

1.12.23
Celia Luterbacher

The HYLAB’s chip with integrated photonic circuit made of lithium niobate © Alain Herzog.

The HYLAB’s chip with integrated photonic circuit made of lithium niobate © Alain Herzog

EPFL researchers have collaborated with those at Harvard and ETH Zurich on a new thin-film circuit that, when connected to a laser beam, produces finely tailorable terahertz-frequency waves. The device opens up a world of potential applications in optics and telecommunications.

Researchers led by Cristina Benea-Chelmus in the Laboratory of Hybrid Photonics (HYLAB) in EPFL’s School of Engineering have taken a big step toward successfully exploiting the so-called “terahertz gap” which lies between about 300-30000 gigahertz (0.3 to 30 THz) on the electromagnetic spectrum. This range is currently something of a technological dead zone, describing frequencies that are too fast for today’s electronics and telecommunications devices, but too slow for optics and imaging applications.

Now, thanks to an extremely thin chip with an integrated photonic circuit made of lithium niobate, the HYLAB researchers and colleagues at ETH Zurich and Harvard University have succeeded not just in producing terahertz waves, but in engineering a solution for custom-tailoring their frequency, wavelength, amplitude, and phase. Such precise control over terahertz radiation means that it can now potentially be harnessed for next-generation applications in both the electronic and optical realms. The results have recently been published in Nature Communications [below].

“Seeing the devices emit radiation with properties that we predefined was a confirmation that our model was correct,“ says co-first author Alexa Herter, currently a PhD student at ETH Zurich.

“This was made possible due to the unique features of lithium niobate integrated photonics,” adds co-first author Amirhassan Shams-Ansari, a postdoctoral fellow at Harvard University.

Telecoms-ready

Benea-Chelmus explains that while such terahertz waves have been produced in a lab setting before, previous approaches have relied primarily on bulk crystals to generate the right frequencies. Her lab’s use of the lithium niobate circuit, finely etched at the nanometer scale by collaborators at Harvard University, makes their novel approach much more streamlined. The use of a silicon substrate also makes the device suitable for integration into electronic and optical systems.

“Generating waves at very high frequencies is extremely challenging, and there are very few techniques that can generate them with unique patterns. We are now able to engineer the exact temporal shape of terahertz waves – to say essentially, ‘I want a waveform that looks like this,’” she explains.

To achieve this, Benea-Chelmus’ lab designed the chip’s arrangement of channels called “waveguides”, from which microscopic antennas broadcast terahertz waves generated by light from optical fibers.

“The fact that our device already makes use of a standard optical signal is really an advantage, because it means that these new chips can be used with traditional lasers, which work very well and are very well understood. It means our device is telecommunications-compatible,” Benea-Chelmus emphasizes. She adds that miniaturized devices that send and receive signals in the terahertz range could play a key role in sixth generation mobile systems (6G).

In the world of optics, Benea-Chelmus sees particular potential for miniaturized lithium niobate chips in spectroscopy and imaging. In addition to being non-ionizing, terahertz waves are much lower-energy than many other types of waves (like x-rays) currently used to provide information about the composition of a material – whether it’s a bone or an oil painting. A compact, non-destructive device like the lithium niobate chip could therefore provide a less invasive alternative to current spectrographic techniques.

“You could imagine sending terahertz radiation through a material you are interested in and analyzing it to measure the response of the material, depending on its molecular structure. All this from a device smaller than a match head.”

Quantum future

Next, Benea-Chelmus plans to focus on tweaking the properties of the chip’s waveguides and antennas to engineer waveforms with greater amplitudes, and more finely tuned frequencies and decay rates. She also sees potential for the terahertz technology developed in her lab to be useful for quantum applications.

“There are many fundamental questions to address; for example, we are interested in whether we can use such chips to generate new types of quantum radiation that can be manipulated on extremely short timescales. Such waves in quantum science can be used to control quantum objects.”

Science paper:
Nature Communications
See the science paper for instructive material with images.

See the full article here .

Comments are invited and will be appreciated, especially if the reader finds any errors which I can correct. Use “Reply”.

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EPFL campus

The Swiss Federal Institute of Technology in Lausanne [EPFL-École Polytechnique Fédérale de Lausanne] (CH) is a research institute and university in Lausanne, Switzerland, that specializes in natural sciences and engineering. It is one of the two Swiss Federal Institutes of Technology, and it has three main missions: education, research and technology transfer.

The QS World University Rankings ranks EPFL(CH) 14th in the world across all fields in their 2020/2021 ranking, whereas Times Higher Education World University Rankings ranks EPFL(CH) as the world’s 19th best school for Engineering and Technology in 2020.

EPFL(CH) is located in the French-speaking part of Switzerland; the sister institution in the German-speaking part of Switzerland is The Swiss Federal Institute of Technology ETH Zürich [Eidgenössische Technische Hochschule Zürich] (CH). Associated with several specialized research institutes, the two universities form The Domain of the Swiss Federal Institutes of Technology (ETH Domain) [ETH-Bereich; Domaine des Écoles Polytechniques Fédérales] (CH) which is directly dependent on the Federal Department of Economic Affairs, Education and Research. In connection with research and teaching activities, EPFL(CH) operates a nuclear reactor CROCUS; a Tokamak Fusion reactor; a Blue Gene/Q Supercomputer; and P3 bio-hazard facilities.

ETH Zürich, EPFL (Swiss Federal Institute of Technology in Lausanne) [École Polytechnique Fédérale de Lausanne](CH), and four associated research institutes form The Domain of the Swiss Federal Institutes of Technology (ETH Domain) [ETH-Bereich; Domaine des Écoles polytechniques fédérales] (CH) with the aim of collaborating on scientific projects.

The roots of modern-day EPFL(CH) can be traced back to the foundation of a private school under the name École Spéciale de Lausanne in 1853 at the initiative of Lois Rivier, a graduate of the École Centrale Paris (FR) and John Gay the then professor and rector of the Académie de Lausanne. At its inception it had only 11 students and the offices were located at Rue du Valentin in Lausanne. In 1869, it became the technical department of the public Académie de Lausanne. When the Académie was reorganized and acquired the status of a university in 1890, the technical faculty changed its name to École d’Ingénieurs de l’Université de Lausanne. In 1946, it was renamed the École polytechnique de l’Université de Lausanne (EPUL). In 1969, the EPUL was separated from the rest of the University of Lausanne and became a federal institute under its current name. EPFL(CH), like ETH Zürich (CH), is thus directly controlled by the Swiss federal government. In contrast, all other universities in Switzerland are controlled by their respective cantonal governments. Following the nomination of Patrick Aebischer as president in 2000, EPFL(CH) has started to develop into the field of life sciences. It absorbed the Swiss Institute for Experimental Cancer Research (ISREC) in 2008.

In 1946, there were 360 students. In 1969, EPFL(CH) had 1,400 students and 55 professors. In the past two decades the university has grown rapidly and as of 2012 roughly 14,000 people study or work on campus, about 9,300 of these being Bachelor, Master or PhD students. The environment at modern day EPFL(CH) is highly international with the school attracting students and researchers from all over the world. More than 125 countries are represented on the campus and the university has two official languages, French and English.

Organization

EPFL is organized into eight schools, themselves formed of institutes that group research units (laboratories or chairs) around common themes:

School of Basic Sciences
Institute of Mathematics
Institute of Chemical Sciences and Engineering
Institute of Physics
European Centre of Atomic and Molecular Computations
Bernoulli Center
Biomedical Imaging Research Center
Interdisciplinary Center for Electron Microscopy
MPG-EPFL Centre for Molecular Nanosciences and Technology
Swiss Plasma Center
Laboratory of Astrophysics

School of Engineering

Institute of Electrical Engineering
Institute of Mechanical Engineering
Institute of Materials
Institute of Microengineering
Institute of Bioengineering

School of Architecture, Civil and Environmental Engineering

Institute of Architecture
Civil Engineering Institute
Institute of Urban and Regional Sciences
Environmental Engineering Institute

School of Computer and Communication Sciences

Algorithms & Theoretical Computer Science
Artificial Intelligence & Machine Learning
Computational Biology
Computer Architecture & Integrated Systems
Data Management & Information Retrieval
Graphics & Vision
Human-Computer Interaction
Information & Communication Theory
Networking
Programming Languages & Formal Methods
Security & Cryptography
Signal & Image Processing
Systems

School of Life Sciences

Bachelor-Master Teaching Section in Life Sciences and Technologies
Brain Mind Institute
Institute of Bioengineering
Swiss Institute for Experimental Cancer Research
Global Health Institute
Ten Technology Platforms & Core Facilities (PTECH)
Center for Phenogenomics
NCCR Synaptic Bases of Mental Diseases

College of Management of Technology

Swiss Finance Institute at EPFL
Section of Management of Technology and Entrepreneurship
Institute of Technology and Public Policy
Institute of Management of Technology and Entrepreneurship
Section of Financial Engineering

College of Humanities

Human and social sciences teaching program

EPFL Middle East

Section of Energy Management and Sustainability

In addition to the eight schools there are seven closely related institutions

Swiss Cancer Centre
Center for Biomedical Imaging (CIBM)
Centre for Advanced Modelling Science (CADMOS)
École Cantonale d’art de Lausanne (ECAL)
Campus Biotech
Wyss Center for Bio- and Neuro-engineering
Swiss National Supercomputing Centre

From The School of Engineering and Applied Science At Yale University: “A Better Photon Detector to Advance Quantum Technology”

Yale SEAS

From The School of Engineering and Applied Science

at

Yale University

1.3.23

Credit: Yale University.

A team of researchers has developed an on-chip photon-counting device that could significantly advance numerous applications of quantum technology.

The laboratory of Hong Tang, the Llewellyn West Jones, Jr. Professor of Electrical Engineering, Applied Physics & Physics, has developed the first realization of an on-chip photon-number-resolving (PNR) detector that can resolve up to 100 photons at a time. This detector shows its power in resolving the photon statistics of a light pulse. The results are published in Nature Photonics [below].

Photon-number-resolving (PNR) detectors are considered the most desired technology for measuring light. With very high sensitivity, they can resolve the number of photons even in an extremely weak light pulse. They’re essential to a vast range of quantum applications, including quantum computing, quantum cryptography and remote sensing. However, current photon counting devices are limited in how many photons they can detect at once – usually only one at a time, and not more than 10.  

“The problem is that if you have more than one, the detector will be saturated, so you cannot tell how many photons you have,” said co-lead author Yiyu Zhou, a postdoctoral associate in Tang’s lab.

The device from the Tang group, though, not only advances PNR capability by up to 100, but also improves by three orders of magnitude on the counting rate. It also operates at an easily accessible temperature. 

Because of this, the device allows for a broader range of applications, Tang said, “especially in lots of fast-emerging quantum applications, such as large-scale Boson sampling, photonic quantum computing, and quantum metrology.” 

The complexity of the device required years of design and fabrication, and then also to verify its performance. 

To build on their work, the researchers plan to make the device smaller and increase the number of photons it can detect. That could include using different dielectric material to boost its photon number resolution to more than 1,000.  

Further, they want to integrate the detector with on-chip quantum light sources. Conventional detectors are designed to be interfaced with an optical fiber, which can lead to signal loss.  

“If we can integrate everything together, we would have lower loss, and a higher fidelity of measurement,” said Risheng Cheng, a former postdoctoral associate in Tang’s lab and currently a research scientist at Meta.

The study’s other authors are Sihao Wang, Mohan Shen, and Towsif Taher. 

Credit: Yale University.

Science paper:
Nature Photonics

See the full article here .

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Yale School of Engineering and Applied Science Daniel L Malone Engineering Center
The Yale School of Engineering & Applied Science is the engineering school of Yale University. When the first professor of civil engineering was hired in 1852, a Yale School of Engineering was established within the Yale Scientific School, and in 1932 the engineering faculty organized as a separate, constituent school of the university. The school currently offers undergraduate and graduate classes and degrees in electrical engineering, chemical engineering, computer science, applied physics, environmental engineering, biomedical engineering, and mechanical engineering and materials science.

Yale University is a private Ivy League research university in New Haven, Connecticut. Founded in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and one of the nine Colonial Colleges chartered before the American Revolution. The Collegiate School was renamed Yale College in 1718 to honor the school’s largest private benefactor for the first century of its existence, Elihu Yale. Yale University is consistently ranked as one of the top universities and is considered one of the most prestigious in the nation.

Chartered by Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale’s faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research.

Yale is organized into fourteen constituent schools: the original undergraduate college, the Yale Graduate School of Arts and Sciences and twelve professional schools. While the university is governed by the Yale Corporation, each school’s faculty oversees its curriculum and degree programs. In addition to a central campus in downtown New Haven, the university owns athletic facilities in western New Haven, a campus in West Haven, Connecticut, and forests and nature preserves throughout New England. As of June 2020, the university’s endowment was valued at $31.1 billion, the second largest of any educational institution. The Yale University Library, serving all constituent schools, holds more than 15 million volumes and is the third-largest academic library in the United States. Students compete in intercollegiate sports as the Yale Bulldogs in the NCAA Division I – Ivy League.

As of October 2020, 65 Nobel laureates, five Fields Medalists, four Abel Prize laureates, and three Turing award winners have been affiliated with Yale University. In addition, Yale has graduated many notable alumni, including five U.S. Presidents, 19 U.S. Supreme Court Justices, 31 living billionaires, and many heads of state. Hundreds of members of Congress and many U.S. diplomats, 78 MacArthur Fellows, 252 Rhodes Scholars, 123 Marshall Scholars, and nine Mitchell Scholars have been affiliated with the university.

Research

Yale is a member of the Association of American Universities (AAU) and is classified among “R1: Doctoral Universities – Very high research activity”. According to the National Science Foundation, Yale spent $990 million on research and development in 2018, ranking it 15th in the nation.

Yale’s faculty include 61 members of the National Academy of Sciences , 7 members of the National Academy of Engineering and 49 members of the American Academy of Arts and Sciences. The college is, after normalization for institution size, the tenth-largest baccalaureate source of doctoral degree recipients in the United States, and the largest such source within the Ivy League.

Yale’s English and Comparative Literature departments were part of the New Criticism movement. Of the New Critics, Robert Penn Warren, W.K. Wimsatt, and Cleanth Brooks were all Yale faculty. Later, the Yale Comparative literature department became a center of American deconstruction. Jacques Derrida, the father of deconstruction, taught at the Department of Comparative Literature from the late seventies to mid-1980s. Several other Yale faculty members were also associated with deconstruction, forming the so-called “Yale School”. These included Paul de Man who taught in the Departments of Comparative Literature and French, J. Hillis Miller, Geoffrey Hartman (both taught in the Departments of English and Comparative Literature), and Harold Bloom (English), whose theoretical position was always somewhat specific, and who ultimately took a very different path from the rest of this group. Yale’s history department has also originated important intellectual trends. Historians C. Vann Woodward and David Brion Davis are credited with beginning in the 1960s and 1970s an important stream of southern historians; likewise, David Montgomery, a labor historian, advised many of the current generation of labor historians in the country. Yale’s Music School and Department fostered the growth of Music Theory in the latter half of the 20th century. The Journal of Music Theory was founded there in 1957; Allen Forte and David Lewin were influential teachers and scholars.

In addition to eminent faculty members, Yale research relies heavily on the presence of roughly 1200 Postdocs from various national and international origin working in the multiple laboratories in the sciences, social sciences, humanities, and professional schools of the university. The university progressively recognized this working force with the recent creation of the Office for Postdoctoral Affairs and the Yale Postdoctoral Association.

Notable alumni

Over its history, Yale has produced many distinguished alumni in a variety of fields, ranging from the public to private sector. According to 2020 data, around 71% of undergraduates join the workforce, while the next largest majority of 16.6% go on to attend graduate or professional schools. Yale graduates have been recipients of 252 Rhodes Scholarships, 123 Marshall Scholarships, 67 Truman Scholarships, 21 Churchill Scholarships, and 9 Mitchell Scholarships. The university is also the second largest producer of Fulbright Scholars, with a total of 1,199 in its history and has produced 89 MacArthur Fellows. The U.S. Department of State Bureau of Educational and Cultural Affairs ranked Yale fifth among research institutions producing the most 2020–2021 Fulbright Scholars. Additionally, 31 living billionaires are Yale alumni.

At Yale, one of the most popular undergraduate majors among Juniors and Seniors is political science, with many students going on to serve careers in government and politics. Former presidents who attended Yale for undergrad include William Howard Taft, George H. W. Bush, and George W. Bush while former presidents Gerald Ford and Bill Clinton attended Yale Law School. Former vice-president and influential antebellum era politician John C. Calhoun also graduated from Yale. Former world leaders include Italian prime minister Mario Monti, Turkish prime minister Tansu Çiller, Mexican president Ernesto Zedillo, German president Karl Carstens, Philippine president José Paciano Laurel, Latvian president Valdis Zatlers, Taiwanese premier Jiang Yi-huah, and Malawian president Peter Mutharika, among others. Prominent royals who graduated are Crown Princess Victoria of Sweden, and Olympia Bonaparte, Princess Napoléon.

Yale alumni have had considerable presence in U.S. government in all three branches. On the U.S. Supreme Court, 19 justices have been Yale alumni, including current Associate Justices Sonia Sotomayor, Samuel Alito, Clarence Thomas, and Brett Kavanaugh. Numerous Yale alumni have been U.S. Senators, including current Senators Michael Bennet, Richard Blumenthal, Cory Booker, Sherrod Brown, Chris Coons, Amy Klobuchar, Ben Sasse, and Sheldon Whitehouse. Current and former cabinet members include Secretaries of State John Kerry, Hillary Clinton, Cyrus Vance, and Dean Acheson; U.S. Secretaries of the Treasury Oliver Wolcott, Robert Rubin, Nicholas F. Brady, Steven Mnuchin, and Janet Yellen; U.S. Attorneys General Nicholas Katzenbach, John Ashcroft, and Edward H. Levi; and many others. Peace Corps founder and American diplomat Sargent Shriver and public official and urban planner Robert Moses are Yale alumni.

Yale has produced numerous award-winning authors and influential writers, like Nobel Prize in Literature laureate Sinclair Lewis and Pulitzer Prize winners Stephen Vincent Benét, Thornton Wilder, Doug Wright, and David McCullough. Academy Award winning actors, actresses, and directors include Jodie Foster, Paul Newman, Meryl Streep, Elia Kazan, George Roy Hill, Lupita Nyong’o, Oliver Stone, and Frances McDormand. Alumni from Yale have also made notable contributions to both music and the arts. Leading American composer from the 20th century Charles Ives, Broadway composer Cole Porter, Grammy award winner David Lang, and award-winning jazz pianist and composer Vijay Iyer all hail from Yale. Hugo Boss Prize winner Matthew Barney, famed American sculptor Richard Serra, President Barack Obama presidential portrait painter Kehinde Wiley, MacArthur Fellow and contemporary artist Sarah Sze, Pulitzer Prize winning cartoonist Garry Trudeau, and National Medal of Arts photorealist painter Chuck Close all graduated from Yale. Additional alumni include architect and Presidential Medal of Freedom winner Maya Lin, Pritzker Prize winner Norman Foster, and Gateway Arch designer Eero Saarinen. Journalists and pundits include Dick Cavett, Chris Cuomo, Anderson Cooper, William F. Buckley, Jr., and Fareed Zakaria.

In business, Yale has had numerous alumni and former students go on to become founders of influential business, like William Boeing (Boeing, United Airlines), Briton Hadden and Henry Luce (Time Magazine), Stephen A. Schwarzman (Blackstone Group), Frederick W. Smith (FedEx), Juan Trippe (Pan Am), Harold Stanley (Morgan Stanley), Bing Gordon (Electronic Arts), and Ben Silbermann (Pinterest). Other business people from Yale include former chairman and CEO of Sears Holdings Edward Lampert, former Time Warner president Jeffrey Bewkes, former PepsiCo chairperson and CEO Indra Nooyi, sports agent Donald Dell, and investor/philanthropist Sir John Templeton,

Yale alumni distinguished in academia include literary critic and historian Henry Louis Gates, economists Irving Fischer, Mahbub ul Haq, and Nobel Prize laureate Paul Krugman; Nobel Prize in Physics laureates Ernest Lawrence and Murray Gell-Mann; Fields Medalist John G. Thompson; Human Genome Project leader and National Institutes of Health director Francis S. Collins; brain surgery pioneer Harvey Cushing; pioneering computer scientist Grace Hopper; influential mathematician and chemist Josiah Willard Gibbs; National Women’s Hall of Fame inductee and biochemist Florence B. Seibert; Turing Award recipient Ron Rivest; inventors Samuel F.B. Morse and Eli Whitney; Nobel Prize in Chemistry laureate John B. Goodenough; lexicographer Noah Webster; and theologians Jonathan Edwards and Reinhold Niebuhr.

In the sporting arena, Yale alumni include baseball players Ron Darling and Craig Breslow and baseball executives Theo Epstein and George Weiss; football players Calvin Hill, Gary Fenick, Amos Alonzo Stagg, and “the Father of American Football” Walter Camp; ice hockey players Chris Higgins and Olympian Helen Resor; Olympic figure skaters Sarah Hughes and Nathan Chen; nine-time U.S. Squash men’s champion Julian Illingworth; Olympic swimmer Don Schollander; Olympic rowers Josh West and Rusty Wailes; Olympic sailor Stuart McNay; Olympic runner Frank Shorter; and others.

From The Massachusetts Institute of Technology: “New sensor uses MRI to detect light deep in the brain”

From The Massachusetts Institute of Technology

12.22.22 [Just today in social media.]
Anne Trafton

Using this approach researchers can map how light spreads in opaque environments.

Using a specialized MRI sensor, MIT engineers have shown that they can detect light deep within tissues such as the brain. Image: iStock.

Imaging light in deep tissues is extremely difficult because as light travels into tissue, much of it is either absorbed or scattered. The MIT team overcame that obstacle by designing a sensor that converts light into a magnetic signal that can be detected by MRI (magnetic resonance imaging).

This type of sensor could be used to map light emitted by optical fibers implanted in the brain, such as the fibers used to stimulate neurons during optogenetic experiments. With further development, it could also prove useful for monitoring patients who receive light-based therapies for cancer, the researchers say.

“We can image the distribution of light in tissue, and that’s important because people who use light to stimulate tissue or to measure from tissue often don’t quite know where the light is going, where they’re stimulating, or where the light is coming from. Our tool can be used to address those unknowns,” says Alan Jasanoff, an MIT professor of biological engineering, brain and cognitive sciences, and nuclear science and engineering.

Jasanoff, who is also an associate investigator at MIT’s McGovern Institute for Brain Research, is the senior author of the study, which appears today in Nature Biomedical Engineering [below]. Jacob Simon PhD ’21 and MIT postdoc Miriam Schwalm are the paper’s lead authors, and Johannes Morstein and Dirk Trauner of New York University are also authors of the paper.

A light-sensitive probe

Scientists have been using light to study living cells for hundreds of years, dating back to the late 1500s, when the light microscope was invented. This kind of microscopy allows researchers to peer inside cells and thin slices of tissue, but not deep inside an organism.

“One of the persistent problems in using light, especially in the life sciences, is that it doesn’t do a very good job penetrating many materials,” Jasanoff says. “Biological materials absorb light and scatter light, and the combination of those things prevents us from using most types of optical imaging for anything that involves focusing in deep tissue.”

To overcome that limitation, Jasanoff and his students decided to design a sensor that could transform light into a magnetic signal.

“We wanted to create a magnetic sensor that responds to light locally, and therefore is not subject to absorbance or scattering. Then this light detector can be imaged using MRI,” he says.

Jasanoff’s lab has previously developed MRI probes that can interact with a variety of molecules in the brain, including dopamine and calcium. When these probes bind to their targets, it affects the sensors’ magnetic interactions with the surrounding tissue, dimming or brightening the MRI signal.

To make a light-sensitive MRI probe, the researchers decided to encase magnetic particles in a nanoparticle called a liposome. The liposomes used in this study are made from specialized light-sensitive lipids that Trauner had previously developed. When these lipids are exposed to a certain wavelength of light, the liposomes become more permeable to water, or “leaky.” This allows the magnetic particles inside to interact with water and generate a signal detectable by MRI.

The particles, which the researchers called liposomal nanoparticle reporters (LisNR), can switch from permeable to impermeable depending on the type of light they’re exposed to. In this study, the researchers created particles that become leaky when exposed to ultraviolet light, and then become impermeable again when exposed to blue light. The researchers also showed that the particles could respond to other wavelengths of light.

“This paper shows a novel sensor to enable photon detection with MRI through the brain. This illuminating work introduces a new avenue to bridge photon and proton-driven neuroimaging studies,” says Xin Yu, an assistant professor radiology at Harvard Medical School, who was not involved in the study.

Mapping light

The researchers tested the sensors in the brains of rats — specifically, in a part of the brain called the striatum, which is involved in planning movement and responding to reward. After injecting the particles throughout the striatum, the researchers were able to map the distribution of light from an optical fiber implanted nearby.

The fiber they used is similar to those used for optogenetic stimulation, so this kind of sensing could be useful to researchers who perform optogenetic experiments in the brain, Jasanoff says.

“We don’t expect that everybody doing optogenetics will use this for every experiment — it’s more something that you would do once in a while, to see whether a paradigm that you’re using is really producing the profile of light that you think it should be,” Jasanoff says.

In the future, this type of sensor could also be useful for monitoring patients receiving treatments that involve light, such as photodynamic therapy, which uses light from a laser or LED to kill cancer cells.

The researchers are now working on similar probes that could be used to detect light emitted by luciferases, a family of glowing proteins that are often used in biological experiments. These proteins can be used to reveal whether a particular gene is activated or not, but currently they can only be imaged in superficial tissue or cells grown in a lab dish.

Jasanoff also hopes to use the strategy used for the LisNR sensor to design MRI probes that can detect stimuli other than light, such as neurochemicals or other molecules found in the brain.

“We think that the principle that we use to construct these sensors is quite broad and can be used for other purposes too,” he says.

The research was funded by the National Institutes of Health, the G. Harold and Leila Y. Mathers Foundation, a Friends of the McGovern Fellowship from the McGovern Institute for Brain Research, the MIT Neurobiological Engineering Training Program, and a Marie Curie Individual Fellowship from the European Commission.

Science paper:
Nature Biomedical Engineering

See the full article here .

Comments are invited and will be appreciated, especially if the reader finds any errors which I can correct. Use “Reply”.

five-ways-keep-your-child-safe-school-shootings
Please help promote STEM in your local schools.

Stem Education Coalition

USPS “Forever” postage stamps celebrating Innovation at MIT.

The Massachusetts Institute of Technology is a private land-grant research university in Cambridge, Massachusetts. The institute has an urban campus that extends more than a mile (1.6 km) alongside the Charles River. The institute also encompasses a number of major off-campus facilities such as the MIT Lincoln Laboratory , the MIT Bates Research and Engineering Center , and the Haystack Observatory , as well as affiliated laboratories such as the Broad Institute of MIT and Harvard and Whitehead Institute.

MIT Lincoln Laboratory campus

Massachusettes Institute of Technology-Haystack Observatory Westford, Massachusetts, USA, Altitude 131 m (430 ft).

The Computer Science and Artificial Intelligence Laboratory (CSAIL)

Founded in 1861 in response to the increasing industrialization of the United States, Massachusetts Institute of Technology adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. It has since played a key role in the development of many aspects of modern science, engineering, mathematics, and technology, and is widely known for its innovation and academic strength. It is frequently regarded as one of the most prestigious universities in the world.

As of December 2020, 97 Nobel laureates, 26 Turing Award winners, and 8 Fields Medalists have been affiliated with MIT as alumni, faculty members, or researchers. In addition, 58 National Medal of Science recipients, 29 National Medals of Technology and Innovation recipients, 50 MacArthur Fellows, 80 Marshall Scholars, 3 Mitchell Scholars, 22 Schwarzman Scholars, 41 astronauts, and 16 Chief Scientists of the U.S. Air Force have been affiliated with The Massachusetts Institute of Technology. The university also has a strong entrepreneurial culture and MIT alumni have founded or co-founded many notable companies. Massachusetts Institute of Technology is a member of the Association of American Universities.

Foundation and vision

In 1859, a proposal was submitted to the Massachusetts General Court to use newly filled lands in Back Bay, Boston for a “Conservatory of Art and Science”, but the proposal failed. A charter for the incorporation of the Massachusetts Institute of Technology, proposed by William Barton Rogers, was signed by John Albion Andrew, the governor of Massachusetts, on April 10, 1861.

Rogers, a professor from the University of Virginia , wanted to establish an institution to address rapid scientific and technological advances. He did not wish to found a professional school, but a combination with elements of both professional and liberal education, proposing that:

“The true and only practicable object of a polytechnic school is, as I conceive, the teaching, not of the minute details and manipulations of the arts, which can be done only in the workshop, but the inculcation of those scientific principles which form the basis and explanation of them, and along with this, a full and methodical review of all their leading processes and operations in connection with physical laws.”

The Rogers Plan reflected the German research university model, emphasizing an independent faculty engaged in research, as well as instruction oriented around seminars and laboratories.

Early developments

Two days after The Massachusetts Institute of Technology was chartered, the first battle of the Civil War broke out. After a long delay through the war years, MIT’s first classes were held in the Mercantile Building in Boston in 1865. The new institute was founded as part of the Morrill Land-Grant Colleges Act to fund institutions “to promote the liberal and practical education of the industrial classes” and was a land-grant school. In 1863 under the same act, the Commonwealth of Massachusetts founded the Massachusetts Agricultural College, which developed as the University of Massachusetts Amherst ). In 1866, the proceeds from land sales went toward new buildings in the Back Bay.

The Massachusetts Institute of Technology was informally called “Boston Tech”. The institute adopted the European polytechnic university model and emphasized laboratory instruction from an early date. Despite chronic financial problems, the institute saw growth in the last two decades of the 19th century under President Francis Amasa Walker. Programs in electrical, chemical, marine, and sanitary engineering were introduced, new buildings were built, and the size of the student body increased to more than one thousand.

The curriculum drifted to a vocational emphasis, with less focus on theoretical science. The fledgling school still suffered from chronic financial shortages which diverted the attention of the MIT leadership. During these “Boston Tech” years, Massachusetts Institute of Technology faculty and alumni rebuffed Harvard University president (and former MIT faculty) Charles W. Eliot’s repeated attempts to merge MIT with Harvard College’s Lawrence Scientific School. There would be at least six attempts to absorb MIT into Harvard. In its cramped Back Bay location, MIT could not afford to expand its overcrowded facilities, driving a desperate search for a new campus and funding. Eventually, the MIT Corporation approved a formal agreement to merge with Harvard, over the vehement objections of MIT faculty, students, and alumni. However, a 1917 decision by the Massachusetts Supreme Judicial Court effectively put an end to the merger scheme.

In 1916, The Massachusetts Institute of Technology administration and the MIT charter crossed the Charles River on the ceremonial barge Bucentaur built for the occasion, to signify MIT’s move to a spacious new campus largely consisting of filled land on a one-mile-long (1.6 km) tract along the Cambridge side of the Charles River. The neoclassical “New Technology” campus was designed by William W. Bosworth and had been funded largely by anonymous donations from a mysterious “Mr. Smith”, starting in 1912. In January 1920, the donor was revealed to be the industrialist George Eastman of Rochester, New York, who had invented methods of film production and processing, and founded Eastman Kodak. Between 1912 and 1920, Eastman donated $20 million ($236.6 million in 2015 dollars) in cash and Kodak stock to MIT.

Curricular reforms

In the 1930s, President Karl Taylor Compton and Vice-President (effectively Provost) Vannevar Bush emphasized the importance of pure sciences like physics and chemistry and reduced the vocational practice required in shops and drafting studios. The Compton reforms “renewed confidence in the ability of the Institute to develop leadership in science as well as in engineering”. Unlike Ivy League schools, Massachusetts Institute of Technology catered more to middle-class families, and depended more on tuition than on endowments or grants for its funding. The school was elected to the Association of American Universities in 1934.

Still, as late as 1949, the Lewis Committee lamented in its report on the state of education at The Massachusetts Institute of Technology that “the Institute is widely conceived as basically a vocational school”, a “partly unjustified” perception the committee sought to change. The report comprehensively reviewed the undergraduate curriculum, recommended offering a broader education, and warned against letting engineering and government-sponsored research detract from the sciences and humanities. The School of Humanities, Arts, and Social Sciences and the MIT Sloan School of Management were formed in 1950 to compete with the powerful Schools of Science and Engineering. Previously marginalized faculties in the areas of economics, management, political science, and linguistics emerged into cohesive and assertive departments by attracting respected professors and launching competitive graduate programs. The School of Humanities, Arts, and Social Sciences continued to develop under the successive terms of the more humanistically oriented presidents Howard W. Johnson and Jerome Wiesner between 1966 and 1980.

The Massachusetts Institute of Technology‘s involvement in military science surged during World War II. In 1941, Vannevar Bush was appointed head of the federal Office of Scientific Research and Development and directed funding to only a select group of universities, including MIT. Engineers and scientists from across the country gathered at Massachusetts Institute of Technology ‘s Radiation Laboratory, established in 1940 to assist the British military in developing microwave radar. The work done there significantly affected both the war and subsequent research in the area. Other defense projects included gyroscope-based and other complex control systems for gunsight, bombsight, and inertial navigation under Charles Stark Draper’s Instrumentation Laboratory; the development of a digital computer for flight simulations under Project Whirlwind; and high-speed and high-altitude photography under Harold Edgerton. By the end of the war, The Massachusetts Institute of Technology became the nation’s largest wartime R&D contractor (attracting some criticism of Bush), employing nearly 4000 in the Radiation Laboratory alone and receiving in excess of $100 million ($1.2 billion in 2015 dollars) before 1946. Work on defense projects continued even after then. Post-war government-sponsored research at MIT included SAGE and guidance systems for ballistic missiles and Project Apollo.

These activities affected The Massachusetts Institute of Technology profoundly. A 1949 report noted the lack of “any great slackening in the pace of life at the Institute” to match the return to peacetime, remembering the “academic tranquility of the prewar years”, though acknowledging the significant contributions of military research to the increased emphasis on graduate education and rapid growth of personnel and facilities. The faculty doubled and the graduate student body quintupled during the terms of Karl Taylor Compton, president of The Massachusetts Institute of Technology between 1930 and 1948; James Rhyne Killian, president from 1948 to 1957; and Julius Adams Stratton, chancellor from 1952 to 1957, whose institution-building strategies shaped the expanding university. By the 1950s, The Massachusetts Institute of Technology no longer simply benefited the industries with which it had worked for three decades, and it had developed closer working relationships with new patrons, philanthropic foundations and the federal government.

In late 1960s and early 1970s, student and faculty activists protested against the Vietnam War and The Massachusetts Institute of Technology ‘s defense research. In this period Massachusetts Institute of Technology’s various departments were researching helicopters, smart bombs and counterinsurgency techniques for the war in Vietnam as well as guidance systems for nuclear missiles. The Union of Concerned Scientists was founded on March 4, 1969 during a meeting of faculty members and students seeking to shift the emphasis on military research toward environmental and social problems. The Massachusetts Institute of Technology ultimately divested itself from the Instrumentation Laboratory and moved all classified research off-campus to the MIT Lincoln Laboratory facility in 1973 in response to the protests. The student body, faculty, and administration remained comparatively unpolarized during what was a tumultuous time for many other universities. Johnson was seen to be highly successful in leading his institution to “greater strength and unity” after these times of turmoil. However, six Massachusetts Institute of Technology students were sentenced to prison terms at this time and some former student leaders, such as Michael Albert and George Katsiaficas, are still indignant about MIT’s role in military research and its suppression of these protests. (Richard Leacock’s film, November Actions, records some of these tumultuous events.)

In the 1980s, there was more controversy at The Massachusetts Institute of Technology over its involvement in SDI (space weaponry) and CBW (chemical and biological warfare) research. More recently, The Massachusetts Institute of Technology’s research for the military has included work on robots, drones and ‘battle suits’.

Recent history

The Massachusetts Institute of Technology has kept pace with and helped to advance the digital age. In addition to developing the predecessors to modern computing and networking technologies, students, staff, and faculty members at Project MAC, the Artificial Intelligence Laboratory, and the Tech Model Railroad Club wrote some of the earliest interactive computer video games like Spacewar! and created much of modern hacker slang and culture. Several major computer-related organizations have originated at MIT since the 1980s: Richard Stallman’s GNU Project and the subsequent Free Software Foundation were founded in the mid-1980s at the AI Lab; the MIT Media Lab was founded in 1985 by Nicholas Negroponte and Jerome Wiesner to promote research into novel uses of computer technology; the World Wide Web Consortium standards organization was founded at the Laboratory for Computer Science in 1994 by Tim Berners-Lee; the MIT OpenCourseWare project has made course materials for over 2,000 Massachusetts Institute of Technology classes available online free of charge since 2002; and the One Laptop per Child initiative to expand computer education and connectivity to children worldwide was launched in 2005.

The Massachusetts Institute of Technology was named a sea-grant college in 1976 to support its programs in oceanography and marine sciences and was named a space-grant college in 1989 to support its aeronautics and astronautics programs. Despite diminishing government financial support over the past quarter century, MIT launched several successful development campaigns to significantly expand the campus: new dormitories and athletics buildings on west campus; the Tang Center for Management Education; several buildings in the northeast corner of campus supporting research into biology, brain and cognitive sciences, genomics, biotechnology, and cancer research; and a number of new “backlot” buildings on Vassar Street including the Stata Center. Construction on campus in the 2000s included expansions of the Media Lab, the Sloan School’s eastern campus, and graduate residences in the northwest. In 2006, President Hockfield launched the MIT Energy Research Council to investigate the interdisciplinary challenges posed by increasing global energy consumption.

In 2001, inspired by the open source and open access movements, The Massachusetts Institute of Technology launched “OpenCourseWare” to make the lecture notes, problem sets, syllabi, exams, and lectures from the great majority of its courses available online for no charge, though without any formal accreditation for coursework completed. While the cost of supporting and hosting the project is high, OCW expanded in 2005 to include other universities as a part of the OpenCourseWare Consortium, which currently includes more than 250 academic institutions with content available in at least six languages. In 2011, The Massachusetts Institute of Technology announced it would offer formal certification (but not credits or degrees) to online participants completing coursework in its “MITx” program, for a modest fee. The “edX” online platform supporting MITx was initially developed in partnership with Harvard and its analogous “Harvardx” initiative. The courseware platform is open source, and other universities have already joined and added their own course content. In March 2009 the Massachusetts Institute of Technology faculty adopted an open-access policy to make its scholarship publicly accessible online.

The Massachusetts Institute of Technology has its own police force. Three days after the Boston Marathon bombing of April 2013, MIT Police patrol officer Sean Collier was fatally shot by the suspects Dzhokhar and Tamerlan Tsarnaev, setting off a violent manhunt that shut down the campus and much of the Boston metropolitan area for a day. One week later, Collier’s memorial service was attended by more than 10,000 people, in a ceremony hosted by the Massachusetts Institute of Technology community with thousands of police officers from the New England region and Canada. On November 25, 2013, The Massachusetts Institute of Technology announced the creation of the Collier Medal, to be awarded annually to “an individual or group that embodies the character and qualities that Officer Collier exhibited as a member of The Massachusetts Institute of Technology community and in all aspects of his life”. The announcement further stated that “Future recipients of the award will include those whose contributions exceed the boundaries of their profession, those who have contributed to building bridges across the community, and those who consistently and selflessly perform acts of kindness”.

In September 2017, the school announced the creation of an artificial intelligence research lab called the MIT-IBM Watson AI Lab. IBM will spend $240 million over the next decade, and the lab will be staffed by MIT and IBM scientists. In October 2018 MIT announced that it would open a new Schwarzman College of Computing dedicated to the study of artificial intelligence, named after lead donor and The Blackstone Group CEO Stephen Schwarzman. The focus of the new college is to study not just AI, but interdisciplinary AI education, and how AI can be used in fields as diverse as history and biology. The cost of buildings and new faculty for the new college is expected to be $1 billion upon completion.

The Caltech/MIT Advanced aLIGO was designed and constructed by a team of scientists from California Institute of Technology , Massachusetts Institute of Technology, and industrial contractors, and funded by the National Science Foundation .

Caltech /MIT Advanced aLigo

It was designed to open the field of gravitational-wave astronomy through the detection of gravitational waves predicted by general relativity. Gravitational waves were detected for the first time by the LIGO detector in 2015. For contributions to the LIGO detector and the observation of gravitational waves, two Caltech physicists, Kip Thorne and Barry Barish, and Massachusetts Institute of Technology physicist Rainer Weiss won the Nobel Prize in physics in 2017. Weiss, who is also a Massachusetts Institute of Technology graduate, designed the laser interferometric technique, which served as the essential blueprint for the LIGO.

The mission of The Massachusetts Institute of Technology is to advance knowledge and educate students in science, technology, and other areas of scholarship that will best serve the nation and the world in the twenty-first century. We seek to develop in each member of The Massachusetts Institute of Technology community the ability and passion to work wisely, creatively, and effectively for the betterment of humankind.