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  • richardmitnick 12:46 pm on June 23, 2016 Permalink | Reply
    Tags: OpenZika project at World Community Grid, , ,   

    From Science Node: “Hacking Zika in the Lone Star state” 

    Science Node bloc
    Science Node

    25 May, 2016 [just put in social media]
    Jorge Salazar

    More than 50 data scientists, engineers, and UT Austin students joined forces at the Austin Zika Hackathon to use big data to fight the spread of Zika.

    Hackathon participants investigated ways to pool together different sets of data — outbreak reports, stagnant water sources, empty swimming pools and ponds that are potential mosquito breeding grounds, and even Facebook and Twitter feeds.

    The Texas Advanced Computing Center (TACC) plans to store all the data on a new data-intensive supercomputer called Wrangler.

    Wrangler is one of the newest Extreme Science and Engineering Discovery Environment (XSEDE) supercomputing resources, and is supported by the National Science Foundation (NSF).

    TACC Wrangler

    “We’re trying to collect these disparate pieces of data, and there’s not a good way for people to ask questions about that data — that’s the big problem,” says Ari Kahn, human translational genomics coordinator at TACC.

    Zika, a mosquito-borne disease that can cause fever and birth defects, threatens to spread to the United States. As of mid-May 2016, Mexico had reported 272 cases of Zika. The problem has grown so large that President Obama has requested $1.9 billion to halt the spread of Zika.

    The US Centers for Disease Control (CDC) is now ramping up collection of data that tracks Zika spread. But big gaps exist in linking different kinds of data, and that makes it tough for experts to predict where it will go next and what to do to prevent it.

    The Zika hackers formed groups and worked on creating demo projects based off of sample CDC and other data. One project developed a working tensor flow model that used machine learning to search through aerial images for pools of stagnant water, potential breeding ground for mosquitos that carry Zika.

    Another team developed a mobile app with nodes that would allow researchers to report developing cases of mosquito-borne illness. One demonstrated a way to map microcephaly occurrences in Brazil using an R maps interface to Leaflet. Another made headway into readying CDC data from Puerto Rico to layer with CIA Fact Book data for richer understanding of how Zika has progressed there.

    “The Zika Hackathon is about bringing awareness and building a platform that is repeatable, not just for the Zika virus data analysis,” says Zika Hackathon organizer Eddie Garcia, chief security architect at Cloudera. “Someone can take what we did here today and apply it to some other unknown outbreak. It’s really about getting people together, excited, bringing awareness, and building out a platform that is repeatable.”

    The Zika Hackathon brought together an emerging kind of scientist, a data scientist. Data scientists specialize both in translating information from many different sources into data that can be used together and in using new technologies by which knowledge can be extracted from today’s massive data collections.

    “There are three classes of work that get put under the umbrella of data science,” says data scientist Juliet Hougland of Cloudera. “1) Data scrubbing – getting data in the right format, in the right place — is a huge part of any job where you’re going to do something useful with that data. 2) Investigative analytics looks at historic data and doing interesting, useful analysis on it. 3) Operational analytics supports recommendation engines, fraud detection systems, and more.”

    At the hackathon, software developer David Walling of TACC’s Data Intensive Computing group spoke of his current research extracting rich data from ‘grey literature,’ unofficial records that can be images inside PDF files, a bane of data scientists. His work uses natural language processing techniques to map occurrences in the grey literature of a given species such as fish at specific locations and dates. Progress on this problem would translate well to getting more information for researchers about Zika.

    “If you can see where all the water sources are and then overlay how the reports of outbreaks are happening, then you can create a model for how it’s spreading and how it will spread in the future based on where the water sources are. Then maybe you can come up with some plans to offset that so the spreading doesn’t happen as fast or doesn’t happen at all,” Kahn says.

    The charitable arm of the data analytics company, Cloudera Cares, along with TACC and other local partners, are planning to hold quarterly hackathons as part of a larger planned project to use big data to battle Zika and other threats. The project will help prevent outbreaks from happening, and make it easier for researchers to get answers.

    To learn more about the Zika outbreak check these resources from the CDC, the World Health Organization, and the European Center for Disease Prevention and Control.

    See the full article here .


    There is a new project at World Community Grid [WCG] called OpenZika.
    Image of the Zika virus

    Rutgers Open Zika

    WCG runs on your home computer or tablet on software from Berkeley Open Infrastructure for Network Computing [BOINC]. Many other scientific projects run on BOINC software.Visit WCG or BOINC, download and install the software, then at WCG attach to the OpenZika project. You will be joining tens of thousands of other “crunchers” processing computational data and saving the scientists literally thousands of hours of work at no real cost to you.

    WCG Logo New

    BOINC WallPaper

    Please help promote STEM in your local schools.
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    Stem Education Coalition

    Science Node is an international weekly online publication that covers distributed computing and the research it enables.

    “We report on all aspects of distributed computing technology, such as grids and clouds. We also regularly feature articles on distributed computing-enabled research in a large variety of disciplines, including physics, biology, sociology, earth sciences, archaeology, medicine, disaster management, crime, and art. (Note that we do not cover stories that are purely about commercial technology.)

    In its current incarnation, Science Node is also an online destination where you can host a profile and blog, and find and disseminate announcements and information about events, deadlines, and jobs. In the near future it will also be a place where you can network with colleagues.

    You can read Science Node via our homepage, RSS, or email. For the complete iSGTW experience, sign up for an account or log in with OpenID and manage your email subscription from your account preferences. If you do not wish to access the website’s features, you can just subscribe to the weekly email.”

  • richardmitnick 6:15 am on June 18, 2016 Permalink | Reply
    Tags: OpenZika project at World Community Grid, ,   

    From Science Alert: “There are now 234 pregnant women in the US with confirmed Zika virus” 


    Science Alert

    Depiction of Zika

    17 JUN 2016

    Officials from the Centres for Disease Control and Prevention (CDC) have confirmed that there are now 234 pregnant women in the continental US carrying the Zika virus – an infection spread by mosquito bites that can cause a devastating birth defect called microcephaly.

    Out of these women, there have been six “abnormalities” – three babies born with birth defects so far, and another three who died before birth – though officials did not say how many of the women have given birth in total, and how many are still pregnant.

    As Sabrina Tavernise from The New York Times points out, the report poses more questions than it gives answers. For example, without knowing the number of babies born, how do we make sense of the six abnormalities? Do these represent a large or small amount of the women infected?

    In response to those questions, one of CDC’s leaders on pregnancy and birth defects, Denise Jamieson, said that the newly released numbers are only the first in a series of updates that will provide more information.

    “We’re sort of in a hard place,” Jamieson told The New York Times. “We can’t provide a lot of information about where these women are in their pregnancy. We don’t want to inadvertently disclose information about difficult decisions these women are making about their pregnancies.”

    The CDC also hasn’t disclosed where any of these women were infected with the virus, or how they came in contact with it.

    So far, we do know that one of the babies was born was microcephaly – a birth defect that causes a baby’s brain to not fully develop during pregnancy, resulting them being born with an abnormally small head and cognitive complications.

    Jamieson said that the risk of an infected woman giving birth to a child with birth defects is around one to 15 percent. “Microcephalic babies are beginning to be born [in the US]” Jamieson said. “The disease seems to be very similar no matter where it is.”

    Though Zika virus can cause major health problems for pregnant women and their unborn children, the infection is usually pretty harmless for most healthy individuals. In fact, roughly 80 percent of those infected never know it. Usually, even if symptoms, such as fever and rash, appear, they only last a few weeks and rarely end in hospital visits.

    The virus was first discovered back in 1947 in monkeys, getting its name from the Zika Forest in Uganda where it was found. The first reported cases of Zika started to emerge in 1952 in Uganda and the United Republic of Tanzania.

    “Before 2007, at least 14 cases of Zika had been documented, although other cases were likely to have occurred and were not reported,” reports the CDC. “Because the symptoms of Zika are similar to those of many other diseases, many cases may not have been recognised.”

    The virus is primarily transmitted through mosquito bites, though men can sexually transmit the disease if they were recently infected before a sexual act. The CDC says that the best way to prevent contracting the illness is to avoid getting bitten in the first place, which is obviously easier said than done. To help with this, the CDC has a full list of prevention methods on their website.

    “What we’re seeing is a very consistent pattern underscoring the fact that Zika causes microcephaly and other severe brain abnormalities,” Jamieson told Lena H. Sun from The Washington Post. “This highlights the importance of preventing unintended pregnancies, avoiding mosquito bites and for pregnant women to avoid traveling to areas with ongoing Zika virus transmission.”

    Despite all of this bad news, scientists are working hard to combat the disease, with several vaccine candidates in development. Back in May, an international team of researchers created a tool that can diagnose Zika in just a 3 hours. So far, though, an effective treatment for pregnant women has remained out of sight.

    See the full article here .


    There is a new project at World Community Grid [WCG] called OpenZika.
    Image of the Zika virus

    Rutgers Open Zika

    WCG runs on your home computer or tablet on software from Berkeley Open Infrastructure for Network Computing [BOINC]. Many other scientific projects run on BOINC software.Visit WCG or BOINC, download and install the software, then at WCG attach to the OpenZika project. You will be joining tens of thousands of other “crunchers” processing computational data and saving the scientists literally thousands of hours of work at no real cost to you.

    WCG Logo New

    BOINC WallPaper

    Please help promote STEM in your local schools.

    STEM Icon

    Stem Education Coalition

  • richardmitnick 9:52 am on June 15, 2016 Permalink | Reply
    Tags: , , , OpenZika project at World Community Grid,   

    From NPR: “Here’s Really Where Zika Mosquitoes Are Likely In The U.S.” 


    National Public Radio (NPR)

    June 13, 2016
    Michaeleen Doucleff

    Counties where Aedes aegypti was reported between Jan. 1, 1995, and March 2016. Counties in yellow recorded one year of A. aegypti being present; those shown in orange recorded two years; and those shown in red, three or more years. Centers for Disease Control and Prevention

    A few months ago, the Centers for Disease Control and Prevention published a startling map that showed the parts of the U.S. that could harbor mosquitoes capable of carrying Zika.

    Many readers, including myself, thought, “Zika could come to my town! It could come to Connecticut! To Ohio and Indiana! Or to Northern California! Oh goodness!”

    The map made it look like a vast swath of the country was at risk for Zika, including New England and the Upper Midwest.

    Well, not quite.

    On Thursday, CDC scientists published another mosquito map for the U.S. And it paints a very different picture.

    The new map shows counties in which scientists, over the past two decades, have collected Aedes aegypti mosquitoes — the type of insect thought to be spreading Zika in Latin American and the Caribbean.

    “The new map is more accurate than the initial one,” says Thomas Scott, an entomologist at the University of California, Davis. “The distribution of the A. aegypti mosquito is much more restricted than the initial map showed.”

    In the map, counties colored yellow reported A. aegypti mosquitoes during one year between 1995 and 2016. Orange counties had the mosquitoes in two years. And red counties are the hot spots: Scientists there found A. aegypti mosquitoes during three or more years in the past two decades.

    This map represents “the best knowledge of the current distribution of this mosquito based on collection records,” entomologist John-Paul Mutebi and his colleagues at the CDC wrote in the Journal of Medical Entomology.

    Many of the hot spots for this mosquito aren’t surprising. They’re places that we already knew are vulnerable to Zika, including counties in southern Florida, along the Gulf Coast and southern Texas. These places have had problems with a virus closely related to Zika, called dengue. They’re already on high alert for Zika.

    But several hot spots are bit more unexpected — and concerning. “Perhaps the most concerning development for A. aegypti is its establishment in the Southwest, most recently in California in 2013,” Mutebi and his co-authors write.

    Other surprises include parts of the Bay Area, greater Washington, D.C., and the Dallas-Fort Worth region, which all have established populations of A. aegypti, the map shows.

    “The country is really a patchwork,” Scott says. “When you drill down into one particular state, you find that the mosquito isn’t found across the whole state. And when you drill down into a county, you find the same thing. The mosquito is found in just a small part.”

    So why did the first map from the CDC make it look like such an extensive part of the country was at risk for Zika?

    “The two maps show different things,” Mutebi tells Shots. “The first map showed where the climate is able to sustain populations of A. aegypti. This new map shows reports from counties where these mosquitoes were found in the last 20 years.”

    And the new map, Mutebi says, is not complete. “Not all counties have mosquito surveillance programs looking for mosquitoes,” he says. In places that do, they are often targeting the mosquito that causes West Nile virus, not A. aegypti.

    “So just because a county hasn’t reported having any A. aegypti mosquitoes doesn’t mean they’re not there,” Mutebi says.

    A. aegypti mosquitoes are nasty critters. They chase down people so they can feed on their blood, says virologist Scott Weaver at the University of Texas Medical Branch in Galveston.

    A. aegypti lives in close association with people, feeds almost exclusively on people — not animals — and even comes into people’s home,” he says. “Its behavior and its ecology are almost ideal for a mosquito to transmit a human virus.”

    See the full article here.


    There is a new project at World Community Grid [WCG] called OpenZika.
    Image of the Zika virus

    Rutgers Open Zika

    WCG runs on your home computer or tablet on software from Berkeley Open Infrastructure for Network Computing [BOINC]. Many other scientific projects run on BOINC software.Visit WCG or BOINC, download and install the software, then at WCG attach to the OpenZika project. You will be joining tens of thousands of other “crunchers” processing computational data and saving the scientists literally thousands of hours of work at no real cost to you.

    WCG Logo New

    BOINC WallPaper
    Please help promote STEM in your local schools.
    STEM Icon

    Stem Education Coalition

    Great storytelling and rigorous reporting. These are the passions that fuel us. Our business is telling stories, small and large, that start conversations, increase understanding, enrich lives and enliven minds.

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  • richardmitnick 5:23 pm on May 19, 2016 Permalink | Reply
    Tags: , , OpenZika project at World Community Grid, ,   

    From World Community Grid and Rutgers University: “Fighting the Zika Virus with the Power of Supercomputing” 

    Rutgers University

    New WCG Logo


    From Rutgers

    Thursday, May 19, 2016

    Rutgers Open Zika

    Rutgers is taking a leading role in an IBM-sponsored World Community Grid project that will use supercomputing power to identify potential drug candidates to cure the Zika virus.

    The project, known as OpenZika, employs a global team of scientists who will perform “virtual” experiments in a search of treatments for the fast-spreading virus that the World Health Organization has declared a global public health emergency.

    OpenZika will screen current drugs and millions of drug-like compounds from existing databases against models of Zika protein structures (and also against structures of proteins from related viruses, including West Nile Virus and Dengue). These computational results will be shared quickly with the research community and general public, with compounds showing the most promise then tested in laboratory settings.

    “Instead of having to wait a number of years, even decades potentially, to test all these compounds in order to find a few that could form the basis of antiviral drugs to cure Zika, we will perform these initial tests in a matter of months, just by using idle computing power that would otherwise go to waste,” says Alex Perryman, a research teaching specialist at Rutgers’ New Jersey Medical School, in Professor Joel Freundlich’s lab.

    OpenZika co-principal investigator Alex Perryman, researcher at Rutgers’ New Jersey Medical School, also managed the World Community Grid’s first biomedical computing project, FightAIDS@Home, and its Global Online Fight Against Malaria (GO FAM). Perryman was selected as co-principal investigator of the OpenZika project, while Freundlich serves as a key consultant.

    Perryman was selected as co-principal investigator of the OpenZika project, while Freundlich serves as a key consultant.

    Rutgers’ Perryman has had deep experience working with IBM’s World Community Grid. From 2007 to 2013, he managed and performed the day-to-day duties required for FightAIDS@Home, the first biomedical computing project on World Community Grid. In 2011, Perryman designed, developed and ran the grid’s Global Online Fight Against Malaria (GO FAM) project, which has resulted in identifying promising tool compounds for treating malaria and drug-resistant tuberculosis.

    In less than two years, GO FAM volunteers on the grid performed more than a billion docking jobs, which, Perryman estimates, would have taken at least 100 years using the computer capacity found at most universities. The Freundlich lab has leveraged GO FAM data against tuberculosis drug targets, along with novel machine learning techniques they have developed, to seed novel therapeutic strategies.

    For the OpenZika project IBM is working with an international team of researchers, led by Federal University of Goias in Brazil; with scientists from the Oswaldo Cruz Foundation (Fiocruz) in Brazil; Rutgers University’s New Jersey Medical School (NJMS); and the University of California, San Diego (UCSD). Carolina Horta Andrade, professor at Federal University of Goias, is the principal investigator. Joining Perryman as co-PI is Sean Ekins, CEO, Collaborations Pharmaceuticals.

    Volunteers can support the OpenZika search for a cure by joining World Community Grid. IBM also invites researchers to submit research project proposals to receive this free resource. For more information about IBM’s philanthropic efforts, visit http://www.citizenIBM.com or follow @CitizenIBM on Twitter.

    From World Community Grid

    WCG Logo New

    Help an International Research Team Fight the Zika Virus

    19 May 2016
    By: Dr. Carolina Horta Andrade
    Universidade Federal de Goiás, Brazil

    The Zika virus was relatively unknown until 2015, when it made headlines due its rapid spread and its link to severe brain-related deficiencies in newborns born to mothers who contracted the virus while pregnant. Dr. Carolina Horta Andrade, the principal investigator for the new OpenZika project, discusses how she and an international team of researchers are using World Community Grid to accelerate the search for an effective anti-Zika treatment.

    Dr. Carolina Horta Andrade, principal investigator for OpenZika


    Few people had heard of the Zika virus before 2015, when it began rapidly spreading in the Americas, particularly in Brazil. The virus is mostly spread by Aedes aegypti mosquitoes, although sexual and blood transmission are also possible. A currently unknown percentage of pregnant women who have contracted the Zika virus have given birth to infants with a condition called microcephaly, which results in severe brain development issues. In other cases, adults and children who contract the Zika virus have suffered paralysis and other neurological problems.

    Currently, there is no treatment for the Zika virus and no vaccine. Given that Zika has quickly become an international public health concern, my team and I are working with researchers here in Brazil as well as in the United States to look for possible treatments, and we are using World Community Grid to accelerate our project.


    The world has become increasingly alarmed about the Zika virus, and with good reason. Until recently there has been little research on this disease, but in the past few months it has been linked to severe brain deficiencies in some infants as well as potential neurological issues in children and adults. As a scientist and a citizen of Brazil, which has been greatly affected by Zika, I am committed to the fight against the virus, but my team and I will need the help of World Community Grid volunteers to provide the massive computational power required for our search for a Zika treatment.

    I am a professor at the Universidade Federal de Goiás (UFG) in Brazil, and the director of LabMol, a university laboratory which searches for treatments for neglected diseases and cancer. My field is medicinal and computational chemistry, with an emphasis on drug design and discovery for neglected diseases. I first became interested in working in this area because these are diseases that do not interest pharmaceutical companies, since they mainly affect marginalized populations in underdeveloped and developing countries. However, these diseases are highly debilitating and, for most of them, there is no adequate drug treatment. Brazil is vulnerable to a number of neglected diseases, such as dengue, malaria, leishmaniasis, schistosomiasis, and others. My greatest desire is to find treatments to improve the lives of thousands of people throughout the world who suffer from these diseases.

    In 2015, I started a project in collaboration with Dr. Sean Ekins, a pharmacologist with extensive research experience, to focus on the development of computational models to identify active compounds against the dengue virus, which is a serious mosquito-borne disease found throughout the world. These active compounds could become candidates for antiviral drugs. We are now at the stage of selecting compounds to start laboratory tests. In January of 2016, when the Zika virus outbreak in Brazil became alarming, Sean and I decided to expand our dengue research, and we included the Zika virus in our work, since these two diseases are from the same family of viruses.

    Dr. Sean Ekins, CEO, Collaborations Pharmaceuticals, Inc.

    Sean invited me and other collaborators to write a perspective paper that was published*in the beginning of 2016, about the need for open drug discovery for the Zika virus. This work grabbed the attention of scientific illustrator John Liebler, who wanted to produce a picture of the complete Zika virion. We are using the illustration he created (shown below) as a visual for the OpenZika project.

    Image copyright John Liebler, http://www.ArtoftheCell.com. All rights reserved. Used by permission.

    John’s interest inspired us to try to model every protein in the Zika virus, which directly led to writing a groundbreaking paper** with homology models of all the proteins of the Zika virus. (Homology models, which are computational, three-dimensional renderings of proteins within an organism, are useful when the structure of a protein is not experimentally known, which is the case with the Zika virus.)

    The OpenZika Research Team

    After Sean and I began our work on the Zika virus, he introduced me to World Community Grid. Sean has also collaborated with Dr. Alexander Perryman of Rutgers University, New Jersey Medical School, who was previously at The Scripps Research Institute where he played a key role in two World Community Grid projects: Fight AIDS@Home and GO Fight Against Malaria. Sean and Alex are both co-principal investigators with me on the OpenZika project.

    Dr. Alexander Perryman, co-primary investigator, and Dr. Joel Freundlich, collaborator, Rutgers University New Jersey Medical School

    The research team also includes my colleagues at UFG, Dr. Rodolpho Braga, Dr. Melina Mottin and Dr. Roosevelt Silva; Dr. Jair L. Siqueira-Neto from University of California, San Diego; and Dr. Wim Degrave of the Oswaldo Cruz Foundation in Brazil, who is already working with World Community Grid on the Uncovering Genome Mysteries project, among others.

    The UFG team includes Dr. Rodolpho Braga, Dr. Carolina Horta Andrade, Dr. Melina Mottin and Dr. Roosevelt Silva (not pictured).

    This large group of collaborators means that the team has every set of skills and experience necessary to conduct this research end-to-end, as some of the researchers are computational modeling experts while others have extensive laboratory experience.

    Our Goals

    The OpenZika project on World Community Grid aims to identify drug candidates to treat the Zika virus in people who have been infected. The project will use software to screen millions of chemical compounds against the target proteins that the Zika virus likely uses to survive and spread in the human body, based on what is known from similar diseases such as dengue virus and yellow fever. As science’s knowledge of the Zika virus increases in the coming months and key proteins are identified, the OpenZika team will use the new knowledge to refine our search.

    Our work on World Community Grid is only the first step in the larger project of discovering a new drug to fight the Zika virus. Next, we will analyze the data obtained from World Community Grid’s virtual screening to choose the compounds that show the most promise. After we have selected and tested compounds that could be effective in killing the Zika virus, we will publish our results. As soon as we have proven that some of the candidate compounds can actually kill or disable the virus in cell-based tests, we and other labs can then modify the molecules to increase their potency against the virus, while ensuring that these modified compounds are safe and non-toxic.

    We are committed to releasing all the results to the public as soon as they are completed, so other scientists can help advance the development of some of these active compounds into new drugs. We hope that OpenZika will include a second stage, where we can perform virtual screenings on many more compounds.

    Without this research–and other projects that are studying the Zika virus–this disease could become an even bigger threat due to the rapid spread of the virus by mosquitoes, blood and sexual transmission. The link between the Zika virus in pregnant women and severe brain-based disorders in children could impact a generation with larger than usual numbers of members who have serious neurological difficulties.

    And without the resources of World Community Grid, using only the resources of our lab, we would only be able to screen a few thousand compounds against some of the Zika proteins, or it would take years to screen millions of compounds against all Zika proteins. This would severely limit our potential for drug discovery.

    Enlisting the help of World Community Grid volunteers will enable us to computationally evaluate over 20 million compounds in just the initial phase (and potentially up to 90 million compounds in future phases). Thus, running the OpenZika project on World Community Grid will allow us to greatly expand the scale of our project, and it will accelerate the rate at which we can obtain the results toward an antiviral drug for the Zika virus.

    By working together and sharing our work with the scientific community, many other researchers in the world will also be able to take promising molecular candidates forward, to accelerate progress towards defeating the Zika outbreak.

    *Science paper:
    Open drug discovery for the Zika virus [version 1; referees: 3 approved]

    **Science paper:
    Illustrating and homology modeling the proteins of the Zika virus [version 1; referees: 1 approved with reservations]

    See the full articles here and here.

    Please help promote STEM in your local schools.
    STEM Icon

    Stem Education Coalition

    World Community Grid (WCG) brings people together from across the globe to create the largest non-profit computing grid benefiting humanity. It does this by pooling surplus computer processing power. We believe that innovation combined with visionary scientific research and large-scale volunteerism can help make the planet smarter. Our success depends on like-minded individuals – like you.”

    WCG projects run on BOINC software from UC Berkeley.

    BOINC is a leader in the field(s) of Distributed Computing, Grid Computing and Citizen Cyberscience.BOINC is more properly the Berkeley Open Infrastructure for Network Computing.

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    “Download and install secure, free software that captures your computer’s spare power when it is on, but idle. You will then be a World Community Grid volunteer. It’s that simple!” You can download the software at either WCG or BOINC.

    Please visit the project pages-


    Rutgers Open Zika

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    Help Cure Muscular Dystrophy

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    World Community Grid is a social initiative of IBM Corporation
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