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  • richardmitnick 9:35 pm on December 1, 2017 Permalink | Reply
    Tags: , , , Mapping Cancer Markers project, ,   

    From Mapping Cancer Markers at WCG: “New Facility and Expanded Plans for the Mapping Cancer Markers Research Team” 

    New WCG Logo

    WCGLarge

    World Community Grid (WCG)

    30 Nov 2017
    Dr. Igor Jurisica
    Krembil Research Institute, University Health Network, Toronto

    Summary
    The Mapping Cancer Markers researchers recently moved to a new institute, but continues analyzing results, planning for expanded research, and creating new work units throughout the transition. Learn about their plans in this article.

    1
    The Mapping Cancer Markers project is currently processing data to identify biomarkers for ovarian cancer, one of the deadliest cancers for women.

    After more than 17 years at Ontario Cancer Institute (now Princess Margaret Cancer Centre), we got an opportunity to join Krembil Research Institute (KRI) to work on a more complex approach to chronic diseases, where we moved in mid-November. KRI is still part of the University Health Network in Toronto, but focuses also on arthritis, neuroscience, and vision. The research and translational clinical research interests focus not only on diagnosis and improved treatment, but importantly on prevention, which aligns with my group’s interest over the last few years.

    Thus, MCM has not been negatively affected—the physical move was smooth, and our severs stayed in the original server rooms, reducing the risk of any hiccup for World Community Grid work units and results. We will not only continue, but will expand on our research.

    New Computational Biology Platform

    Importantly, we are in the finalizing stages of paperwork to embark on a newly-funded research by the Ontario Government: The Next Generation Signalling Biology Platform. This will provide us funds to create a software infrastructure for the comprehensive, integrative computational biology analyses workflows, in collaboration with translational research and clinical trials groups. Our partners are Princess Margaret Cancer Centre, Krembil Research Institute, University of Toronto, University of Montreal, BC Cancer Agency, Cancer Clinical Trials Group, Queen’s University, and European Bioinformatics Institute (IMEx Consortium). Besides focusing on cancer, this is our first large osteo-arthritis research project.

    Thank you to everyone for your support, and we look forward to providing additional updates as our work progresses.

    See the full article here.

    Ways to access the blog:
    https://sciencesprings.wordpress.com
    http://facebook.com/sciencesprings

    Please help promote STEM in your local schools.
    STEM Icon

    Stem Education Coalition

    World Community Grid (WCG) brings people together from across the globe to create the largest non-profit computing grid benefiting humanity. It does this by pooling surplus computer processing power. We believe that innovation combined with visionary scientific research and large-scale volunteerism can help make the planet smarter. Our success depends on like-minded individuals – like you.”
    WCG projects run on BOINC software from UC Berkeley.
    BOINCLarge

    BOINC is a leader in the field(s) of Distributed Computing, Grid Computing and Citizen Cyberscience.BOINC is more properly the Berkeley Open Infrastructure for Network Computing.

    BOINC WallPaper

    CAN ONE PERSON MAKE A DIFFERENCE? YOU BET!!

    My BOINC
    MyBOINC
    “Download and install secure, free software that captures your computer’s spare power when it is on, but idle. You will then be a World Community Grid volunteer. It’s that simple!” You can download the software at either WCG or BOINC.

    Please visit the project pages-
    Smash Childhood Cancer4

    FightAIDS@home Phase II

    FAAH Phase II
    OpenZika

    Rutgers Open Zika

    Help Stop TB
    WCG Help Stop TB
    Outsmart Ebola together

    Outsmart Ebola Together

    Mapping Cancer Markers
    mappingcancermarkers2

    Uncovering Genome Mysteries
    Uncovering Genome Mysteries

    Say No to Schistosoma

    GO Fight Against Malaria

    Drug Search for Leishmaniasis

    Computing for Clean Water

    The Clean Energy Project

    Discovering Dengue Drugs – Together

    Help Cure Muscular Dystrophy

    Help Fight Childhood Cancer

    Help Conquer Cancer

    Human Proteome Folding

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    World Community Grid is a social initiative of IBM Corporation
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  • richardmitnick 3:31 pm on April 21, 2016 Permalink | Reply
    Tags: , , Mapping Cancer Markers project,   

    From Mapping Cancer Markers at WCG: “Mapping Cancer Markers Now Examining Ovarian Cancer” 

    New WCG Logo
    WCGLarge

    21 Apr 2016
    The Mapping Cancer Markers research team

    Summary
    The Mapping Cancer Markers project now includes markers for the most common form of ovarian cancer, with a goal to understand the how this disease progresses from early-stage to late-stage.

    The Mapping Cancer Markers project, which had been concentrating on lung cancer, now includes work units related to ovarian cancer. The researchers are seeking to identify the genes that are important in differentiating between early-stage and late-stage ovarian cancer.

    The Goals of Mapping Cancer Markers

    Cancer is caused by genetic or environmental changes that interfere with biological mechanisms that control cell growth. These changes can be detected in tissue samples through the presence of their unique chemical indicators, such as DNA and proteins, which together are known as “markers.” Specific combinations of these markers may be associated with a given type of cancer. Additionally, the pattern of markers can determine whether an individual is susceptible to developing a specific form of cancer, and may also predict the progression of the disease, helping to suggest the best treatment for a given individual. In order to identify these markers, the project is analyzing millions of data points collected from thousands of healthy and cancerous patient tissue samples.

    Why Ovarian Cancer?

    Around the world, nearly 250,000 women are diagnosed with ovarian cancer each year, and it is responsible for 140,000 deaths each year. Statistics show that just 45 percent of women with ovarian cancer survive for five years. The main types of ovarian cancer are epithelial, germ cell and stromal cell, with the epithelial type accounting for roughly 85-90 percent of all cases. Ovarian cancer often goes undetected in early stages due to the disease being confined to the ovary, the subtlety of the symptoms, and the lack of an effective screening tool. Therefore, most presentations of the disease are detected in late stages or once the cancer has spread outside the ovary, making treatment less effective and less likely to succeed. It is for these reasons that we have chosen epithelial ovarian cancer as our next area of study.

    Understanding the Progression of Ovarian Cancer

    In the next stage of Mapping Cancer Markers, we will attempt to identify important genes in defining the differences between early and late-stage cancers. There is a strong correlation between survival time and cancer stage; patients with early-stage cancer tend to have longer lives. We will be using a curated database of ovarian cancer survival data developed by researchers around the world as a starting point.

    For the purposes of this study, we are defining early-stage death as before three years after diagnosis, and late-stage death as more than four years after diagnosis. We are looking for the genes that are important in differentiating between these two classes of ovarian cancer to allow us to understand the underlying mechanisms of how cancer progresses.

    As compared to the earlier work of Mapping Cancer Markers, where we studied lung cancer, this phase will have a larger and more complex dataset. We estimate that the number of “experiments” we can perform within a single work unit will be much less, as each experiment will take longer to solve. Although the dataset is larger, that means that we are able to use our algorithm against many more points of data, which will hopefully return a very clear result.

    We thank the thousands of World Community Grid volunteers who have supported this project since its launch in 2013, and look forward to continuing to work with you as our research progresses.

    See the full article here.

    Please help promote STEM in your local schools.
    STEM Icon

    Stem Education Coalition

    World Community Grid (WCG) brings people together from across the globe to create the largest non-profit computing grid benefiting humanity. It does this by pooling surplus computer processing power. We believe that innovation combined with visionary scientific research and large-scale volunteerism can help make the planet smarter. Our success depends on like-minded individuals – like you.”

    WCG projects run on BOINC software from UC Berkeley.

    BOINC is a leader in the field(s) of Distributed Computing, Grid Computing and Citizen Cyberscience.BOINC is more properly the Berkeley Open Infrastructure for Network Computing.

    BOINC WallPaper

    CAN ONE PERSON MAKE A DIFFERENCE? YOU BET!!

    “Download and install secure, free software that captures your computer’s spare power when it is on, but idle. You will then be a World Community Grid volunteer. It’s that simple!” You can download the software at either WCG or BOINC.

    Please visit the project pages-

    Help Stop TB
    WCG Help Stop TB
    Outsmart Ebola together

    Outsmart Ebola Together

    Mapping Cancer Markers
    mappingcancermarkers2

    Uncovering Genome Mysteries
    Uncovering Genome Mysteries

    Say No to Schistosoma

    GO Fight Against Malaria

    Drug Search for Leishmaniasis

    Computing for Clean Water

    The Clean Energy Project

    Discovering Dengue Drugs – Together

    Help Cure Muscular Dystrophy

    Help Fight Childhood Cancer

    Help Conquer Cancer

    Human Proteome Folding

    FightAIDS@Home

    World Community Grid is a social initiative of IBM Corporation
    IBM Corporation
    ibm

    IBM – Smarter Planet
    sp

     
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