From “Penn Today” At The University of Pennsylvania : “At the Penn Center for Innovation new discoveries for societal benefit” 

From “Penn Today”


U Penn bloc

The University of Pennsylvania

Dee Patel

Credit: Eric Sucar

The Penn Center for Innovation (PCI) is “the premier university innovation, venture creation, and commercialization center,” says Associate Vice Provost for Research and Managing Director John Swartley.

The center helps translate discoveries and ideas created at Penn into new products and businesses for societal benefit.

“I am truly excited about the future, and the opportunity and privilege of helping Penn innovators translate their ideas into real world solutions,” Swartley says. “It’s been a huge amount of work, but I’m 100% confident that we have the right team and structure to continue to accelerate innovation at Penn.”

The Penn Center for Innovation’s Celebration of Innovation on Tuesday, Dec. 6, will honor the patent recipients from this past fiscal year, as well as select partners, inventors, and startups that made exceptional achievements. The event will take place at the Glandt Forum in the Singh Center for Nanotechnology at 3205 Walnut St. from 4 to 5:30 p.m.

The Center also recently released its annual Year In Review. Inside this report, readers can learn more about the different ways that PCI catalyzed another record-breaking year for commercialization activity at Penn across multiple different technology sectors, further extending and expanding the University’s already prodigious global innovation impact.

Swartley talks to Penn Today about what the Penn Center for Innovation is and some notable accomplishments and highlights.

At the December 2021 Celebration of Innovation, the Penn ICorps team describes their startup idea. (Image: Penn Center for Innovation)

What is the Penn Center for Innovation?

Formally launched in 2014, we help faculty, staff, and student innovators translate the discoveries and ideas they create at Penn into new products and businesses for societal impact and benefit. Unlike most licensing and commercialization offices at other universities, PCI differentiates itself as a one-stop shop for virtually every type of potential business relationship between Penn innovators and their partners in the commercial sector. The expert staff at PCI is highly adept at helping to structure mutually beneficial business arrangements across a wide range of industries and technology development interests. Every day at PCI, we help convene a variety of deals and commercial partnerships, including startup companies, corporate alliances, and technology access agreements that result in the translational advancement of important technologies and innovative business ideas created at Penn, frequently inclusive of significant inflows of sponsored research funding.

One of the things that I often say to help explain the key difference between PCI and other more typical university technology transfer offices is that while traditional offices focus mainly on the ‘patent license’ transaction itself, PCI is more concerned with creating meaningful partnership connections and business relationships between Penn innovators and the private sector. Our philosophy is that if you get these types of vital connections right, the optimal business structure, transactional needs, and contractual agreements will naturally follow.

Talk about some of the major accomplishments highlighted in this year’s report.

We hit record levels in numerous categories across our key metrics dashboard in FY22. To me, this is absolute validation of the philosophical underpinnings of PCI and our single-minded focus on providing world-class client service to all our stakeholders across the University and building productive relationships with external partners. The number of executed commercial agreements is a great example of this. Prior to the launch of PCI, Penn typically entered into 200-250 commercial agreements per year, but nowadays that figure has nearly tripled, and we routinely enter into more than 700 agreements per year. These agreements are with startups and established companies alike, and they now form a broad, robust, and diverse pipeline and portfolio of commercial and translative activity.

That is extraordinary growth, and the results of unleashing so much commercial activity is increasingly evident in the number of Penn startups that are launched and receive professional investor capital, as well as the substantial and transformative flows of licensing income back to the University that is available to further support a broad range of research activities at Penn. It’s a truly virtuous cycle that we hope will generate lasting returns for the University for many years to come.

What is a key highlight for this fiscal year?

There are so many highlights to choose from, but the one that really stands out for me for FY22 is the patient impact story. Penn expertise and technologies licensed from the University are key components in nearly two dozen FDA-approved drugs and devices, directly impacting and improving the lives of more than a billion human beings. These approved treatments include numerous small molecule and cell-based cancer therapies, gene therapies for genetic diseases, and a recently approved surgical device. This ever-growing list of approved treatments also includes the two most widely deployed COVID vaccines currently available, Comirnaty® and Spikevax®, both of which rely upon foundational mRNA technology discovered at Penn by Drew Weissman and Katalin Karikó.

How does PCI help provide Penn innovations and inventors with the best chance to advance the University’s strategic goals and impact the world at large?

The incredible and ever-expanding Penn mRNA story mentioned previously is a perfect example of how the technology nurturing, protection, and commercial partnership support provided by PCI is so vitally important to the overall innovative process at the University. At the time of Weissman’s and Karikó’s fundamental mRNA discoveries nearly two decades ago, it would have been virtually impossible to predict the immense and unprecedented impact their invention would eventually have on worldwide health, and in the midst of an unforeseen global pandemic to boot. But that is precisely what is so important about academic technology commercialization in direct support of promising early stage technologies at world-class research institutions like Penn. By encouraging, protecting, and seeking development partners for hundreds, if not thousands, of discoveries and inventions before it has become fully apparent that they will actually become products and make a societal impact, University programs like PCI play a critically important role in the overall continuum of technology development and eventual social impact.

PCI’s model facilitates an efficient and comprehensive service for faculty through a variety of means. Talk about some of those initiatives.

At PCI, we’re always interested in refining and expanding the range of services and products we offer to our many different innovation clients. During FY22, we were pleased to support complementary innovation efforts across the University, including programs and centers in the School of Engineering and Applied Science (SEAS), the School of Dental Medicine, and Wharton. We supported a SEAS-led initiative focused on the internet of things for agricultural technology development, and we entered into a new drug-development accelerator program with Autobahn Labs. These are just a few examples drawn from many, but they emphasize our commitment to understanding the diverse needs of our clients across the entire University and bringing new business connections and solutions to the table to meet those needs.

Anything else you would like to add?

I would like to take a few moments to specifically recognize my amazing staff and team at PCI who do the heavy lifting every day and deserve a large share of the credit for PCI’s achievements. I’d also like to express my sincere gratitude to my predecessor Mike Cleare, my visionary boss Dawn Bonnell, former President Amy Gutmann, and Penn’s entire executive leadership team and Board of Trustees. Their consistent support and encouragement over the last decade has been absolutely vital to ensuring the success of this groundbreaking new model in support of innovation at Penn. Of course, none of this would be possible without the amazing creativity, inventiveness, and relentless energy of Penn’s world-class faculty and research community.

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Academic life at University of Pennsylvania is unparalleled, with 100 countries and every U.S. state represented in one of the Ivy League’s most diverse student bodies. Consistently ranked among the top 10 universities in the country, Penn enrolls 10,000 undergraduate students and welcomes an additional 10,000 students to our world-renowned graduate and professional schools.

Penn’s award-winning educators and scholars encourage students to pursue inquiry and discovery, follow their passions, and address the world’s most challenging problems through an interdisciplinary approach.

The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. The university claims a founding date of 1740 and is one of the nine colonial colleges chartered prior to the U.S. Declaration of Independence. Benjamin Franklin, Penn’s founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum.

Penn has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences; the School of Engineering and Applied Science; the Wharton School; and the School of Nursing. Penn’s “One University Policy” allows students to enroll in classes in any of Penn’s twelve schools. Among its highly ranked graduate and professional schools are a law school whose first professor wrote the first draft of the United States Constitution, the first school of medicine in North America (Perelman School of Medicine, 1765), and the first collegiate business school (Wharton School, 1881).

Penn is also home to the first “student union” building and organization (Houston Hall, 1896), the first Catholic student club in North America (Newman Center, 1893), the first double-decker college football stadium (Franklin Field, 1924 when second deck was constructed), and Morris Arboretum, the official arboretum of the Commonwealth of Pennsylvania. The first general-purpose electronic computer (ENIAC) was developed at Penn and formally dedicated in 1946. In 2019, the university had an endowment of $14.65 billion, the sixth-largest endowment of all universities in the United States, as well as a research budget of $1.02 billion. The university’s athletics program, the Quakers, fields varsity teams in 33 sports as a member of the NCAA Division I Ivy League conference.

As of 2018, distinguished alumni and/or Trustees include three U.S. Supreme Court justices; 32 U.S. senators; 46 U.S. governors; 163 members of the U.S. House of Representatives; eight signers of the Declaration of Independence and seven signers of the U.S. Constitution (four of whom signed both representing two-thirds of the six people who signed both); 24 members of the Continental Congress; 14 foreign heads of state and two presidents of the United States, including Donald Trump. As of October 2019, 36 Nobel laureates; 80 members of the American Academy of Arts and Sciences; 64 billionaires; 29 Rhodes Scholars; 15 Marshall Scholars and 16 Pulitzer Prize winners have been affiliated with the university.


The University of Pennsylvania considers itself the fourth-oldest institution of higher education in the United States, though this is contested by Princeton University and Columbia University. The university also considers itself as the first university in the United States with both undergraduate and graduate studies.

In 1740, a group of Philadelphians joined together to erect a great preaching hall for the traveling evangelist George Whitefield, who toured the American colonies delivering open-air sermons. The building was designed and built by Edmund Woolley and was the largest building in the city at the time, drawing thousands of people the first time it was preached in. It was initially planned to serve as a charity school as well, but a lack of funds forced plans for the chapel and school to be suspended. According to Franklin’s autobiography, it was in 1743 when he first had the idea to establish an academy, “thinking the Rev. Richard Peters a fit person to superintend such an institution”. However, Peters declined a casual inquiry from Franklin and nothing further was done for another six years. In the fall of 1749, now more eager to create a school to educate future generations, Benjamin Franklin circulated a pamphlet titled Proposals Relating to the Education of Youth in Pensilvania, his vision for what he called a “Public Academy of Philadelphia”. Unlike the other colonial colleges that existed in 1749—Harvard University, William & Mary, Yale Unversity, and The College of New Jersey—Franklin’s new school would not focus merely on education for the clergy. He advocated an innovative concept of higher education, one which would teach both the ornamental knowledge of the arts and the practical skills necessary for making a living and doing public service. The proposed program of study could have become the nation’s first modern liberal arts curriculum, although it was never implemented because Anglican priest William Smith (1727-1803), who became the first provost, and other trustees strongly preferred the traditional curriculum.

Franklin assembled a board of trustees from among the leading citizens of Philadelphia, the first such non-sectarian board in America. At the first meeting of the 24 members of the board of trustees on November 13, 1749, the issue of where to locate the school was a prime concern. Although a lot across Sixth Street from the old Pennsylvania State House (later renamed and famously known since 1776 as “Independence Hall”), was offered without cost by James Logan, its owner, the trustees realized that the building erected in 1740, which was still vacant, would be an even better site. The original sponsors of the dormant building still owed considerable construction debts and asked Franklin’s group to assume their debts and, accordingly, their inactive trusts. On February 1, 1750, the new board took over the building and trusts of the old board. On August 13, 1751, the “Academy of Philadelphia”, using the great hall at 4th and Arch Streets, took in its first secondary students. A charity school also was chartered on July 13, 1753 by the intentions of the original “New Building” donors, although it lasted only a few years. On June 16, 1755, the “College of Philadelphia” was chartered, paving the way for the addition of undergraduate instruction. All three schools shared the same board of trustees and were considered to be part of the same institution. The first commencement exercises were held on May 17, 1757.

The institution of higher learning was known as the College of Philadelphia from 1755 to 1779. In 1779, not trusting then-provost the Reverend William Smith’s “Loyalist” tendencies, the revolutionary State Legislature created a University of the State of Pennsylvania. The result was a schism, with Smith continuing to operate an attenuated version of the College of Philadelphia. In 1791, the legislature issued a new charter, merging the two institutions into a new University of Pennsylvania with twelve men from each institution on the new board of trustees.

Penn has three claims to being the first university in the United States, according to university archives director Mark Frazier Lloyd: the 1765 founding of the first medical school in America made Penn the first institution to offer both “undergraduate” and professional education; the 1779 charter made it the first American institution of higher learning to take the name of “University”; and existing colleges were established as seminaries (although, as detailed earlier, Penn adopted a traditional seminary curriculum as well).

After being located in downtown Philadelphia for more than a century, the campus was moved across the Schuylkill River to property purchased from the Blockley Almshouse in West Philadelphia in 1872, where it has since remained in an area now known as University City. Although Penn began operating as an academy or secondary school in 1751 and obtained its collegiate charter in 1755, it initially designated 1750 as its founding date; this is the year that appears on the first iteration of the university seal. Sometime later in its early history, Penn began to consider 1749 as its founding date and this year was referenced for over a century, including at the centennial celebration in 1849. In 1899, the board of trustees voted to adjust the founding date earlier again, this time to 1740, the date of “the creation of the earliest of the many educational trusts the University has taken upon itself”. The board of trustees voted in response to a three-year campaign by Penn’s General Alumni Society to retroactively revise the university’s founding date to appear older than Princeton University, which had been chartered in 1746.

Research, innovations and discoveries

Penn is classified as an “R1” doctoral university: “Highest research activity.” Its economic impact on the Commonwealth of Pennsylvania for 2015 amounted to $14.3 billion. Penn’s research expenditures in the 2018 fiscal year were $1.442 billion, the fourth largest in the U.S. In fiscal year 2019 Penn received $582.3 million in funding from the National Institutes of Health.

In line with its well-known interdisciplinary tradition, Penn’s research centers often span two or more disciplines. In the 2010–2011 academic year alone, five interdisciplinary research centers were created or substantially expanded; these include the Center for Health-care Financing; the Center for Global Women’s Health at the Nursing School; the $13 million Morris Arboretum’s Horticulture Center; the $15 million Jay H. Baker Retailing Center at Wharton; and the $13 million Translational Research Center at Penn Medicine. With these additions, Penn now counts 165 research centers hosting a research community of over 4,300 faculty and over 1,100 postdoctoral fellows, 5,500 academic support staff and graduate student trainees. To further assist the advancement of interdisciplinary research President Amy Gutmann established the “Penn Integrates Knowledge” title awarded to selected Penn professors “whose research and teaching exemplify the integration of knowledge”. These professors hold endowed professorships and joint appointments between Penn’s schools.

Penn is also among the most prolific producers of doctoral students. With 487 PhDs awarded in 2009, Penn ranks third in the Ivy League, only behind Columbia University and Cornell University (Harvard University did not report data). It also has one of the highest numbers of post-doctoral appointees (933 in number for 2004–2007), ranking third in the Ivy League (behind Harvard and Yale University) and tenth nationally.

In most disciplines Penn professors’ productivity is among the highest in the nation and first in the fields of epidemiology, business, communication studies, comparative literature, languages, information science, criminal justice and criminology, social sciences and sociology. According to the National Research Council nearly three-quarters of Penn’s 41 assessed programs were placed in ranges including the top 10 rankings in their fields, with more than half of these in ranges including the top five rankings in these fields.

Penn’s research tradition has historically been complemented by innovations that shaped higher education. In addition to establishing the first medical school; the first university teaching hospital; the first business school; and the first student union Penn was also the cradle of other significant developments. In 1852, Penn Law was the first law school in the nation to publish a law journal still in existence (then called The American Law Register, now the Penn Law Review, one of the most cited law journals in the world). Under the deanship of William Draper Lewis, the law school was also one of the first schools to emphasize legal teaching by full-time professors instead of practitioners, a system that is still followed today. The Wharton School was home to several pioneering developments in business education. It established the first research center in a business school in 1921 and the first center for entrepreneurship center in 1973 and it regularly introduced novel curricula for which BusinessWeek wrote, “Wharton is on the crest of a wave of reinvention and change in management education”.

Several major scientific discoveries have also taken place at Penn. The university is probably best known as the place where the first general-purpose electronic computer (ENIAC) was born in 1946 at the Moore School of Electrical Engineering.


It was here also where the world’s first spelling and grammar checkers were created, as well as the popular COBOL programming language. Penn can also boast some of the most important discoveries in the field of medicine. The dialysis machine used as an artificial replacement for lost kidney function was conceived and devised out of a pressure cooker by William Inouye while he was still a student at Penn Med; the Rubella and Hepatitis B vaccines were developed at Penn; the discovery of cancer’s link with genes; cognitive therapy; Retin-A (the cream used to treat acne), Resistin; the Philadelphia gene (linked to chronic myelogenous leukemia) and the technology behind PET Scans were all discovered by Penn Med researchers. More recent gene research has led to the discovery of the genes for fragile X syndrome, the most common form of inherited mental retardation; spinal and bulbar muscular atrophy, a disorder marked by progressive muscle wasting; and Charcot–Marie–Tooth disease, a progressive neurodegenerative disease that affects the hands, feet and limbs.

Conductive polymer was also developed at Penn by Alan J. Heeger, Alan MacDiarmid and Hideki Shirakawa, an invention that earned them the Nobel Prize in Chemistry. On faculty since 1965, Ralph L. Brinster developed the scientific basis for in vitro fertilization and the transgenic mouse at Penn and was awarded the National Medal of Science in 2010. The theory of superconductivity was also partly developed at Penn, by then-faculty member John Robert Schrieffer (along with John Bardeen and Leon Cooper). The university has also contributed major advancements in the fields of economics and management. Among the many discoveries are conjoint analysis, widely used as a predictive tool especially in market research; Simon Kuznets’s method of measuring Gross National Product; the Penn effect (the observation that consumer price levels in richer countries are systematically higher than in poorer ones) and the “Wharton Model” developed by Nobel-laureate Lawrence Klein to measure and forecast economic activity. The idea behind Health Maintenance Organizations also belonged to Penn professor Robert Eilers, who put it into practice during then-President Nixon’s health reform in the 1970s.

International partnerships

Students can study abroad for a semester or a year at partner institutions such as the London School of Economics(UK), University of Barcelona [Universitat de Barcelona](ES), Paris Institute of Political Studies [Institut d’études politiques de Paris](FR), University of Queensland(AU), University College London(UK), King’s College London(UK), Hebrew University of Jerusalem(IL) and University of Warwick(UK).