From DOE’s Sandia National Laboratories (US) : “Pathways to production”

From DOE’s Sandia National Laboratories (US)

August 30, 2021

Paul Rhien
prhien@sandia.gov
925-294-6452

Comprehensive Sandia software aids scientists in synthetic biology analysis.

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A graphic illustration of the kind of retrosynthetic analysis conducted by RetSynth software developed at Sandia National Laboratories. Using a novel algorithm, the software identifies the biological or chemical reactions needed to create a desired biological product or compound. Graphic by Laura Hatfield.

Biologists at Sandia National Laboratories developed comprehensive software that will help scientists in a variety of industries create engineered chemicals more quickly and easily. Sandia is now looking to license the software for commercial use, researchers said.

Sandia’s stand-alone software RetSynth uses a novel algorithm to sort through large, curated databases of biological and chemical reactions, which could help scientists synthetically engineer compounds used in the production of biofuels, pharmaceuticals, cosmetics, industrial chemicals, dyes, scents and flavors.

The software platform uses retrosynthetic analysis to help scientists identify possible pathways to production — the series of biological and chemical reactions, or steps, needed to engineer and modify the molecules in a cell — to create the desired biological product or compound. By using the software to rapidly analyze all pathways, scientists can determine the production sequence with the fewest steps, the sequences that can be completed with available resources or the most economically viable process.

Synthetic biology involves redesigning organisms for useful purposes by engineering them to have new abilities. Researchers and companies around the world are using synthetic biology to harness the power of nature to solve problems in medicine — such as the development of vaccines, antibodies and therapeutic treatments — as well as in manufacturing and agriculture.

“Synthetic biology is becoming a critical capability for U.S. manufacturing. It has the potential to dramatically reduce waste, eliminate or curtail emissions and create next-generation therapeutics and materials,” said Corey Hudson, a computational biologist at Sandia. “That is where people will see RetSynth have the biggest impact.”

“The diverse functionality of RetSynth opens a lot of opportunities for researchers, giving them multiple options, including biological, chemical or hybrid pathways to production,” Hudson said. “All the while, the software is accelerating the research and development process associated with bioproduction. Traditionally, this process has been relatively slow and complex.”

RetSynth is designed to save researchers time and money by suggesting process modifications to maximize theoretical yield, or the amount of bioproduct that could be produced, Hudson said. All available pathways are rendered using clear visual images, enabling software users to quickly interpret results.

Commercial licensing for broader impact

The RetSynth software was originally developed as part of the Department of Energy’s Co-Optimization of Fuels & Engines initiative, a consortium of national lab, university and industry researchers who are creating innovative fuels and combining them with high-efficiency engines to reduce emissions and boost fuel economy.

Today, RetSynth has been expanded to support a variety of diverse applications, and Sandia is ready to license the software to an industry partner for commercial use, Hudson said.

Transfer of Sandia’s innovative technologies to the marketplace through outside technology partners leads to billions in economic impact and supports tens of thousands of high-paying jobs each year, according to a recent report.

To learn more about licensing opportunities, visit Sandia’s Licensing and Technology Transfer webpage.

See the full article here .


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Sandia Campus.

DOE’s Sandia National Laboratories (US) managed and operated by the National Technology and Engineering Solutions of Sandia (a wholly owned subsidiary of Honeywell International), is one of three National Nuclear Security Administration(US) research and development laboratories in the United States. Their primary mission is to develop, engineer, and test the non-nuclear components of nuclear weapons and high technology. Headquartered in Central New Mexico near the Sandia Mountains, on Kirtland Air Force Base in Albuquerque, Sandia also has a campus in Livermore, California, next to DOE’sLawrence Livermore National Laboratory(US), and a test facility in Waimea, Kauai, Hawaii.

It is Sandia’s mission to maintain the reliability and surety of nuclear weapon systems, conduct research and development in arms control and nonproliferation technologies, and investigate methods for the disposal of the United States’ nuclear weapons program’s hazardous waste.

Other missions include research and development in energy and environmental programs, as well as the surety of critical national infrastructures. In addition, Sandia is home to a wide variety of research including computational biology; mathematics (through its Computer Science Research Institute); materials science; alternative energy; psychology; MEMS; and cognitive science initiatives.

Sandia formerly hosted ASCI Red, one of the world’s fastest supercomputers until its recent decommission, and now hosts ASCI Red Storm supercomputer, originally known as Thor’s Hammer.


Sandia is also home to the Z Machine.

The Z Machine is the largest X-ray generator in the world and is designed to test materials in conditions of extreme temperature and pressure. It is operated by Sandia National Laboratories to gather data to aid in computer modeling of nuclear guns. In December 2016, it was announced that National Technology and Engineering Solutions of Sandia, under the direction of Honeywell International, would take over the management of Sandia National Laboratories starting on May 1, 2017.