From RIKEN: “Visualizing whole-body cancer metastasis at the single-cell level”

RIKEN bloc

RIKEN

July 6, 2017
Adam Phillips
RIKEN International Affairs Division
Tel: +81-(0)48-462-1225 /
Fax: +81-(0)48-463-3687
pr@riken.jp

1
3D analysis of the metastatic patterns in experimental brain metastasis models

Researchers at the RIKEN Quantitative Biology Center (QBiC) and the University of Tokyo (UTokyo) have developed a method to visualize cancer metastasis in whole organs at the single-cell level. Published in Cell Reports, the study describes a new method that combines the generation of transparent mice with statistical analysis to create 3-D maps of cancer cells throughout the body and organs.

Recent research in optical clearing methods has made it possible to transparentize the bodies and organs of experimental animals. This has led to a new wave of anatomical studies that can combine tissue transparency with sophisticated cell-labeling techniques and light microscopy. Led by Hiroki Ueda at RIKEN QBiC/UTokyo and Kohei Miyazono at the UTokyo, the team has focused their efforts on being able to visualize and profile cancer metastasis throughout the body.

“One of the biggest difficulties in studying cancer,” explains co-senior author Ueda, “is that tumor metastasis is started by just a few metastasized cells. Our new method makes it possible to image the whole body down to the individual cell level, and therefore we can detect cancer at spatial resolutions beyond what is possible using other current imaging techniques.”

See the full article here .

Please help promote STEM in your local schools.

STEM Icon

Stem Education Coalition

RIKEN campus

RIKEN is Japan’s largest comprehensive research institution renowned for high-quality research in a diverse range of scientific disciplines. Founded in 1917 as a private research foundation in Tokyo, RIKEN has grown rapidly in size and scope, today encompassing a network of world-class research centers and institutes across Japan.

Advertisements