From DESY: “High-tech microscopes for infection research”



German Research Council grants co-financing of five electron cryo-microscopes at CSSB

The German Research Council DFG has granted the Universität Hamburg co-financing for establishing a 15.6 million Euro electron cryo-microscopy facility in the new Centre for Structural Systems Biology (CSSB) on the DESY campus. The German Federal Government will provide 50 per cent of the overall financing and the city of Hamburg will provide the other 50 per cent. The CSSB is a joint initiative of ten research partners from Northern Germany, including DESY. CSSB devotes itself to infection biology and medicine by utilizing structural and molecular biology methods and imaging techniques in conjunction with systems biology approaches.

The planned five electron cryo-microscopes will be funded as part of the German Research Council’s major research instrumentation program.

Typical electron cryo-microscope, this one at Northwestern University, Chicago, USA

They will complement the research opportunities at DESY’s ultra-bright X-ray light sources.

View into the main accelerator tunnel of European XFEL, where 100 superconducting accelerator modules are being installed (Photo: Dirk Nölle, DESY)

Both methods enable three-dimensional imaging of biological structures at the molecular level. With the new super microscopes, scientists plan to study the complex molecular structures and function of pathogens as well as their interactions with host cell components such as proteins and membranes. The insights gained from this research will contribute to the identification of critical steps in the infection process and to the development of novel intervention strategies.

“The investment in the pioneering electron cryo-microscopy in Hamburg is of national importance,” emphasised Hamburg’s Senator for Science, Research and Equality, Katharina Fegebank. “Infection researchers from all over Germany will come to the Bahrenfeld campus to use the microscopes and to pursue their research at the ultra-bright DESY light sources.”

Matthias Wilmanns, Scientific Director of CSSB, emphasized: “The establishment of a state-of-the-art electron cryo-microscopy research infrastructure is a key element in CSSB’s overall research concept. This facility will provide our scientist with the technology to expand our understanding of host-pathogen interactions and tackle some of the most demanding scientific challenges in infection biology.”

The CSSB is a joint venture of ten academic partners: Universität Hamburg, the University Medical Center Hamburg-Eppendorf (UKE), the Bernhard Nocht Institute for Tropical Medicine (BNITM), the Research Center Borstel (FZB), the European Molecular Biology Laboratory (EMBL), Forschungszentrum Jülich (FZJ), the Hannover Medical School (MHH), the Heinrich Pette Institute, Leibniz Institute for Experimental Virology (HPI), the Helmholtz Centre for Infection Research (HZI), and DESY. The different CSSB research groups will investigate pathogens from all three organism groups: viruses, bacteria, and eukaryotic parasites.

See the full article here .

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DESY is one of the world’s leading accelerator centres. Researchers use the large-scale facilities at DESY to explore the microcosm in all its variety – from the interactions of tiny elementary particles and the behaviour of new types of nanomaterials to biomolecular processes that are essential to life. The accelerators and detectors that DESY develops and builds are unique research tools. The facilities generate the world’s most intense X-ray light, accelerate particles to record energies and open completely new windows onto the universe. 
That makes DESY not only a magnet for more than 3000 guest researchers from over 40 countries every year, but also a coveted partner for national and international cooperations. Committed young researchers find an exciting interdisciplinary setting at DESY. The research centre offers specialized training for a large number of professions. DESY cooperates with industry and business to promote new technologies that will benefit society and encourage innovations. This also benefits the metropolitan regions of the two DESY locations, Hamburg and Zeuthen near Berlin.