FROM WCG: “Better tools for AIDS drug research”

FAAH
FightAIDS@home

FightAIDS@Home is a project run by the Olson Laboratory that uses distributed computing to contribute your computer’s idle resources to accelerate research into new drug therapies for HIV, the virus that causes AIDS. FightAIDS@Home made history in September 2000 when it became the first biomedical Internet-based grid computing project. FightAIDS@Home was started with Scott Kurowski, founder of Entropia. People all around the World continue to donate their home computer’s idle cycles to running our AutoDock software on HIV-1 protease inhibitor docking problems. With the generous assistance of IBM, we joined World Community Grid in late 2005, and launched FightAIDS@Home on World Community Grid on 21 November, 2005.

How do I join the FightAIDS@Home Project?

All you need to do is download and install the free client software. Once you have done this, your computer is then automatically put to work and you can continue using your computer as usual.


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24 Jun 2014

Summary
The Scripps research team published a paper proving the effectiveness of a method to more accurately predict bindings between protein targets and drug candidates, which could benefit FightAIDS@Home and other World Community Grid drug discovery projects.

Paper Title:

“Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein–ligand binding challenge”

Lay Person Abstract:

The Olson Lab at The Scripps Institute collaborated to participate in the “SAMPL4 Challenge” which evaluated methods to predict protein target to drug candidate bindings. Olson’s lab in cooperation with Levy’s lab at Rutgers University were able to prove the utility of a method to reduce false positives and therefore potentially reduce the amount of laboratory work required to validate computational results. This should ultimately be a benefit to research projects such as FightAIDS@Home and other drug search projects on World Community Grid.

A link to the paper is here.
See the full article here.

World Community Grid (WCG) brings people together from across the globe to create the largest non-profit computing grid benefiting humanity. It does this by pooling surplus computer processing power. We believe that innovation combined with visionary scientific research and large-scale volunteerism can help make the planet smarter. Our success depends on like-minded individuals – like you.”

WCG projects run on BOINC software from UC Berkeley.

BOINC is a leader in the field(s) of Distributed Computing, Grid Computing and Citizen Cyberscience.BOINC is more properly the Berkeley Open Infrastructure for Network Computing.

CAN ONE PERSON MAKE A DIFFERENCE? YOU BETCHA!!

“Download and install secure, free software that captures your computer’s spare power when it is on, but idle. You will then be a World Community Grid volunteer. It’s that simple!” You can download the software at either WCG or BOINC.

Please visit the project pages-

Say No to Schistosoma
sch

GO Fight Against Malaria
mal

Drug Search for Leishmaniasis
lish

Computing for Clean Water
c4cw

The Clean Energy Project
cep2

Discovering Dengue Drugs – Together
dengue

Help Cure Muscular Dystrophy
md

Help Fight Childhood Cancer
hccf

Help Conquer Cancer
hcc

Human Proteome Folding
hpf

FightAIDS@Home
faah

Computing for Sustainable Water

Computing for Sustainable Water

World Community Grid is a social initiative of IBM Corporation
IBM Corporation
ibm

IBM – Smarter Planet
sp


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