An INL Fact Sheet: “Microbial Metabolic Systems”

Description
The Microbial Metabolic Systems focus at INL is a systems biology approach to more effectively understanding and controlling microbial processes. An enhanced understanding of key microbial processes is being gained by coupling existing genomics, transcriptomics, and proteomics efforts with new metabolomic techniques and data. We use hypothesis-driven research to investigate the impacts of environment, perturbations and manipulations on microbial systems for the purpose of controlling the products and applications of those systems.

Our focus is on developing and using advanced metabolomic techniques to study C-1 prokaryotes. Our definition of “C-1” includes a variety of prokaryotic metabolic systems that involve the transformation of single-carbon compounds. We have targeted specific C-1 metabolic processes of interest to the Department of Energy (DOE):

Methanogenesis – methane production by methanogenic bacteria
Methanotrophy – methane/methanol utilization by methanotrophic bacteria
Bioleaching – carbon fixation in chemoautolithotrophic bacteria and
archaea (e.g., Acidithiobacillus ferrooxidans, Acidianus spp., etc.)
Calcite Precipitation – subsurface calcite precipitationt by urea hydrolyzing bacteria
Bicarbonate Transport – photoautotrophic carbon fixation by cyanobacteria
Hydrogenase Systems – hydrogen production by Carboxydothermus hydrogenoformans.

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Our focus is on developing and using advanced metabolomic techniques to study C-1 prokaryotes. Our definition of “C-1” includes a variety of prokaryotic metabolic systems that involve the transformation of single-carbon compounds. We have targeted specific C-1 metabolic processes of interest to the Department of Energy (DOE)

INL is leveraging existing research programs and expertise in C-1 microbial metabolic systems to develop a recognized capability that will be more broadly applied to other microbial systems relevant to DOE missions.”

See the full Fact Sheet here. There is a lot more information.